Campo DC | Valor | Idioma |
dc.contributor.author | Damasceno, Karine Araújo | - |
dc.contributor.author | Bertagnolli, Angélica Cavalheiro | - |
dc.contributor.author | Lima, Alessandra Estrela da Silva | - |
dc.contributor.author | Ribeiro, Lorena G. R. | - |
dc.contributor.author | Rabelo, Bruna S. | - |
dc.contributor.author | Campos, Cecília Bonolo de | - |
dc.contributor.author | Barros, André Luis Branco de | - |
dc.contributor.author | Cassali, Geovanni Dantas | - |
dc.creator | Damasceno, Karine Araújo | - |
dc.creator | Bertagnolli, Angélica Cavalheiro | - |
dc.creator | Lima, Alessandra Estrela da Silva | - |
dc.creator | Ribeiro, Lorena G. R. | - |
dc.creator | Rabelo, Bruna S. | - |
dc.creator | Campos, Cecília Bonolo de | - |
dc.creator | Barros, André Luis Branco de | - |
dc.creator | Cassali, Geovanni Dantas | - |
dc.date.accessioned | 2013-05-28T20:01:13Z | - |
dc.date.available | 2013-05-28T20:01:13Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/11472 | - |
dc.description.abstract | Background: Components of the extracellular matrix have been studied in an attempt to elucidate the
mechanisms involved in the biological behaviour of tumours. The presence of the proteoglycan versican has been
strongly associated with cancer development and progression. However, relationship between versican expression
and clinical pathological factors and overall survival has not been previously studied in veterinary medicine.
Carcinomas in benign mixed tumours (CBMTs) are one of the most common malignant tumours in female canines
and can serve as models for studies of tumour progression. The aim of this study was to evaluate the expression of
versican in in situ and invasive carcinomatous areas of canine CBMTs and to evaluate possible associations of
versican expression with other classic prognostic factors and overall survival.
Results: Clinical staging; histological grade determination; immunohistochemical staining for versican, E-cadherin
and Ki-67; and confirmation of invasion areas by staining for p63 and smooth muscle α-actin (α-SMA) were
performed on 49 canine cases of CBMT. Tumour invasion was considered when suspicious Haematoxylin-Eosin
(HE)-stained areas showed a total loss of α-SMA and p63 immunoreactivity. Versican immunoreactivity was less
intense in the areas adjacent to the in situ carcinomatous regions, compared to invasive regions, which showed
extensive and strong staining.
Conclusions: Our data reveal that in canine CBMTs, versican expression differs significantly between invasive and
in situ areas, suggesting a role for this molecule in tumour progression. Although a direct relationship exists
between versican and invasiveness, our results indicate that the isolated evaluation of this proteoglycan does not
represent an independent prognostic factor in canine CBMTs. | pt_BR |
dc.language.iso | en_US | pt_BR |
dc.publisher | Veterinary Research | pt_BR |
dc.source | http://www.biomedcentral.com/1746-6148/8/195 | pt_BR |
dc.subject | Versican | pt_BR |
dc.subject | Mixed tumour | pt_BR |
dc.subject | Carcinoma | pt_BR |
dc.subject | Invasion | pt_BR |
dc.subject | Canine | pt_BR |
dc.title | Versican expression in canine carcinomas in benign mixed tumours: is there an association with clinical pathological factors, invasion and overall survival? | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 8 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV)
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