https://repositorio.ufba.br/handle/ri/12720
Tipo: | Artigo de Periódico |
Título: | Anti-leishmanial ige antibodies: a marker of active disease in visceral leishmaniasis |
Título(s) alternativo(s): | The American Society of Tropical Medicine and Hygiene |
Autor(es): | Atta, Ajax Mercês D'Oliveira Junior, Argemiro Correa, Jefferson Atta, Maria Luiza Brito de Sousa Almeida, Roque Pacheco de Carvalho Filho, Edgar Marcelino de |
Autor(es): | Atta, Ajax Mercês D'Oliveira Junior, Argemiro Correa, Jefferson Atta, Maria Luiza Brito de Sousa Almeida, Roque Pacheco de Carvalho Filho, Edgar Marcelino de |
Abstract: | Abstract. Visceral leishmaniasis (VL) is characterized by a depression of the T helper cell type 1 immune response. Although mRNA expression for interleukin-4 (IL-4) is observed, evidence of the role of this cytokine in the pathogenesis of VL has been lacking. Since IL-4 is involved in IgE synthesis, we measured the total IgE and Leishmania antigen-specific IgE antibody levels in sera from patients with VL. Specific IgE antibodies detected by an ELISA technique after absorbing the sera with purified sheep IgG anti-human IgG were found in all 23 patients with VL and were not detected in subjects with subclinical Leishmania chagasi infection (n 5 10), Chagas’ disease (n 5 10), atopic patients (n 5 10), and healthy controls (n 5 10). Levels of Leishmania-specific IgE (optical density values) before and after treatment were 0.100 6 0.03 (mean 6 SD) and 0.028 6 0.002, respectively (P , 0.05). These results indicate that a specific IgE response is useful in the diagnosis of active disease and to evaluate response to treatment. |
Palavras-chave: | Leishmaniose visceral |
Editora / Evento / Instituição: | The American Society of Tropical Medicine and Hygiene |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/12720 |
Data do documento: | 1998 |
Aparece nas coleções: | Artigo Publicado em Periódico (FAR) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
4444444444444444444444.pdf | 79,15 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.