https://repositorio.ufba.br/handle/ri/12762
Campo DC | Valor | Idioma |
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dc.contributor.author | Luz, P. A. | - |
dc.contributor.author | Andrade, L. | - |
dc.contributor.author | Miranda, N. | - |
dc.contributor.author | Pereira, V. | - |
dc.contributor.author | Fregoneze, J. | - |
dc.contributor.author | Silva, E. de Castro e | - |
dc.creator | Luz, P. A. | - |
dc.creator | Andrade, L. | - |
dc.creator | Miranda, N. | - |
dc.creator | Pereira, V. | - |
dc.creator | Fregoneze, J. | - |
dc.creator | Silva, E. de Castro e | - |
dc.date.accessioned | 2013-08-27T17:39:53Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0143-4179 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/12762 | - |
dc.description | Texto completo: acesso restrito.p.85–94 | pt_BR |
dc.description.abstract | In the present study we investigated, the effect of third ventricle injections of IL-1β on water intake, in rats, induced by three different physiological stimuli: dehydration induced by water deprivation, hypernatremia associated with hyperosmolarity induced by intragastric salt load, and hypovolemia produced by subcutaneous polytethyleneglycol administration. Central administration of IL-1β at the doses of 4 and 8 ng reduced water intake in all three conditions studied. Third ventricle injections of IL-1β (8 ng) were unable to diminish water intake in the groups of rats pretreated with central injections of the non-selective opioid antagonist naloxone (10 μg) in the three different conditions studied. Furthermore, the central administration of IL-1β was neither able to modify the intake of a 0.1% saccharin solution when the animals were submitted to a “dessert test” nor to induce any significant locomotor deficit in the open-field test. These results suggest that the central activation of interleukin-1 receptors by IL-1β is able to impair the thirst-inducing mechanisms triggered by the physiological stimuli represented by dehydration, hyperosmolarity and hypovolemia. These results lead us to conclude that the antidipsogenic effects observed following central administration of IL-1β require the functional integrity of the brain opiatergic system. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/j.npep.2005.11.001 | pt_BR |
dc.subject | Opioids | pt_BR |
dc.subject | Naloxone | pt_BR |
dc.subject | Water intake | pt_BR |
dc.subject | Hyperosmolarity | pt_BR |
dc.subject | Hypovolemia | pt_BR |
dc.subject | Dehydration | pt_BR |
dc.title | Inhibition of water intake by the central administration of IL-1β in rats: Role of the central opioid system | pt_BR |
dc.title.alternative | Neuropeptides | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.40 n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
Arquivo | Descrição | Tamanho | Formato | |
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1-s2.0-S0143417905001290-main.pdf Restricted Access | 277,45 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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