Further studies on long-term contraception by subcutaneous silastic R capsules containing megestrol acetate

Abstract

The contraceptive effectiveness of megestrol acetate (M.A.) implants was evaluated in 126 parous young women. Each patient received 5 implants. Each implant contained 23 mg of M.A. A total of 1,560 cycles were recorded. Only one pregnancy occurred in patients observed for up to 15 months for over 1,440 cycles. Three pregnancies occurred in a group of 20 patients whose capsules were replaced by a new set at the end of the first 15-month trial period. The variation in contraceptive effectiveness and the incidence of side effects of this method compared to other methods is discussed.