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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/13414
Tipo: Artigo de Periódico
Título: Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection
Título(s) alternativo(s): Journal of Immunology
Autor(es): Novais, Fernanda Oliveira
Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
Autor(es): Novais, Fernanda Oliveira
Santiago, Rômulo Carvalho
Báfica, Andre Luiz Barbosa
Cunha, Antônio Ricardo Khouri
Macêdo, Lilian Maria Afonso de
Borges, Valéria de Matos
Brodskyn, Claudia Ida
Barral-Netto, Manoel
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
Abstract: Neutrophils play an active role in the control of infections caused by intracellular pathogens such as Leishmania. In the present study, we investigated the effect of neutrophil depletion at the time of Leishmania braziliensis infection of BALB/c mice and how neutrophils interact with the infected macrophage to promote parasite elimination. The in vivo depletion of neutrophils led to a significant increase in parasite load and enhanced the Th1-Th2 immune response in this experimental model of infection. BALB/c mice coinoculated with both parasites and live neutrophils displayed lower parasite burdens at the site of infection and in the draining lymph nodes. In vitro, we observed that live neutrophils significantly reduced the parasite load in L. braziliensis-infected murine macrophages, an effect not observed with Leishmania major. L. braziliensis elimination was dependent on the interaction between neutrophils and macrophages and was associated with TNF-α as well as superoxide production. Furthermore, cooperation between neutrophils and macrophages toward parasite elimination was also observed in experiments performed with L. braziliensis-infected human cells and, importantly, with two other New World Leishmania species. These results indicate that neutrophils play an important and previously unappreciated role in L. braziliensis infection, favoring the induction of a protective immune response.
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/13414
Data do documento: 2009
Aparece nas coleções:Artigo Publicado em Periódico (Biologia)

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