https://repositorio.ufba.br/handle/ri/13490
Tipo: | Artigo de Periódico |
Título: | Prevalence of hepatitis C virus infection and HCV genotypes among hemophiliacs in the State of Bahia, Northeastern Brazil: analysis of serological and virological parameters |
Título(s) alternativo(s): | Revista da Sociedade Brasileira de Medicina Tropical |
Autor(es): | Paraná, Raymundo Reis, Galvão dos Silva, Luciano Kalabric Silva, Maria Betânia Souza da Lopes, Gisele Barreto Rodart, Itatiana Ferreira Costa, Fernando Quadros Santana, Nelma Pereira de Santana, Aurelino |
Autor(es): | Paraná, Raymundo Reis, Galvão dos Silva, Luciano Kalabric Silva, Maria Betânia Souza da Lopes, Gisele Barreto Rodart, Itatiana Ferreira Costa, Fernando Quadros Santana, Nelma Pereira de Santana, Aurelino |
Abstract: | The objective of the present study was to analyze HCV serological and virological parameters from hemophiliacs in the State of Bahia. Anti-HCV was investigated by ELISA in a cohort of 268 hemophiliacs A/B who were followed-up in a reference unit for hemotherapy in the State of Bahia. HCV viremia and genotypes were also determined from a subset of 66 anti-HCV seropositive hemophiliacs. Seroprevalence among hemophiliacs was 42.2% (95% CI 36.5-48.1) and was significantly higher (p<0.05) according to age >10 years, presence of factor VIII/IX inhibitory antibodies and other infection markers. None of the hemophiliacs less than 5 years of age were anti-HCV seropositive. Viremia was detectable in 77.3% (51/66). HCV genotype 1 (74%) was the most prevalent followed by genotype 3 (22%) and genotype 2 (4%). Our results indicate that HCV prevalence is still high among hemophiliacs, although HCV transmission was not observed in young hemophiliacs. |
Palavras-chave: | Hepatitis C virus Hemophilia Prevalence Genotype Bahia |
País: | Brasil |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13490 |
Data do documento: | 2005 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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a10v38n6.pdf | 376,87 kB | Adobe PDF | Visualizar/Abrir |
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