https://repositorio.ufba.br/handle/ri/13523
Tipo: | Artigo de Periódico |
Título: | The protective effect of ß-carotene on genotoxicity induced by cyclophosphamide_0 |
Título(s) alternativo(s): | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
Autor(es): | Salvadori, Daisy M. F. Ribeiro, Lúcia R. Oliveira, Marília de Dirceu Machado de Pereira, Carlos A. B. Beçak, Willy |
Autor(es): | Salvadori, Daisy M. F. Ribeiro, Lúcia R. Oliveira, Marília de Dirceu Machado de Pereira, Carlos A. B. Beçak, Willy |
Abstract: | The influence of ß-carotene on the clastogenicity of the indirect-acting mutagen cyclophosphamide (CPA) was investigated in mice, in vivo, for the induction of chromosome aberrations in bone marrow cells (BM). ß-Carotene (0.5, 1.0, 2.0, 5.0, 10, 25, 50, 100 and 200 mg/kg) was administered by gavage for 5 consecutive days. 4 h after the last treatment with ß-carotene, the mice were injected intraperitoneally with CPA, and the BM cells were fixed after 16, 24 and 32 h for the evaluation of the frequency of chromosome aberrations. The results showed that ß-carotene was effective in reducing chromosomal damage induced by CPA with the increase of its concentration up to a level after which this effect was not observed. This anticlastogenicity was better detected when the cells were fixed at 32 h, although a tendency in reducing the CPA clastogenicity was already observed at 16 and 24 h. Our results suggest that ß-carotene provides significant protection against the genotoxicity of CPA, although no dose-effect relationship on the frequencies of cells with chromosomal aberrations was observed. |
Palavras-chave: | Antimutagenesis ß-Carotene Chromosome aberration Cyclophosphamide |
Editora / Evento / Instituição: | Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13523 |
Data do documento: | 1992 |
Aparece nas coleções: | Artigo Publicado em Periódico (EMV) |
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55555555555555555.pdf_8 | 514,85 kB | Adobe PDF | Visualizar/Abrir |
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