https://repositorio.ufba.br/handle/ri/13631
Tipo: | Artigo de Periódico |
Título: | Infective Dermatitis and Human T Cell Lymphotropic Virus Type 1–Associated Myelopathy/Tropical Spastic Paraparesis in Childhood and Adolescence |
Título(s) alternativo(s): | Clinical Infectious Diseases |
Autor(es): | Bittencourt, Achilea Candida Lisboa Leite Primo, Janeusa Rita Brites, Carlos Oliveira, Maria de Fátima Santos Paim de Carvalho, Otávio Moreno |
Autor(es): | Bittencourt, Achilea Candida Lisboa Leite Primo, Janeusa Rita Brites, Carlos Oliveira, Maria de Fátima Santos Paim de Carvalho, Otávio Moreno |
Abstract: | Background. Human T cell lymphotropic virus type 1 (HTLV-1)–associated infective dermatitis (IDH) is a chronic and recurrent eczema occurring during childhood and adolescence. HTLV-1–associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy of adulthood, presenting with slowly progressive spastic paraparesis and sphincter dysfunction with mild sensory involvement. There are few reports describing an association between IDH and HAM/TSP. The objective of this study was to evaluate the occurrence of HAM/TSP in patients with IDH and in seropositive members of their families and to determine the blood levels of antibodies against HTLV-1 in patients with HAM/TSP. Methods. Twenty patients with IDH and their seropositive mothers and siblings underwent clinical, neurological, and laboratory evaluations. The diagnosis of HAM/TSP was made in accordance with the World Health Organization criteria. Results. Nine individuals had HAM/TSP (6 of the patients with IDH, 2 mothers, and 1 seropositive brother). In 3 families, >1 individual had HAM/TSP. The serum antibody titers of the patients with HAM/TSP varied from 1 : 3.125 to 1 : 78.125. Conclusions. A strong association was observed between IDH and HAM/TSP. The familial clustering of both diseases suggests a genetic background. Serological screening for HTLV-1 in children with symptoms of myelopathy is essential in areas where HTLV-1 is endemic. |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13631 |
Data do documento: | 2005 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Achiléa L..pdf | 93,91 kB | Adobe PDF | Visualizar/Abrir |
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