Campo DC | Valor | Idioma |
dc.contributor.author | Peixinho, Solange | - |
dc.contributor.author | Oliveira, Maria Fernanda de | - |
dc.contributor.author | Oliveira, Jaine Honorata Hortolan Luis de | - |
dc.contributor.author | Galetti, Fabio Cícero de Sá | - |
dc.contributor.author | Souza, Ana Olívia de | - |
dc.contributor.author | Silva, Célio Lopes | - |
dc.contributor.author | Hajdu, Eduardo | - |
dc.contributor.author | Berlinck, Roberto Gomes de Souza | - |
dc.creator | Peixinho, Solange | - |
dc.creator | Oliveira, Maria Fernanda de | - |
dc.creator | Oliveira, Jaine Honorata Hortolan Luis de | - |
dc.creator | Galetti, Fabio Cícero de Sá | - |
dc.creator | Souza, Ana Olívia de | - |
dc.creator | Silva, Célio Lopes | - |
dc.creator | Hajdu, Eduardo | - |
dc.creator | Berlinck, Roberto Gomes de Souza | - |
dc.date.accessioned | 2013-11-19T20:17:35Z | - |
dc.date.issued | 2006 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13768 | - |
dc.description | Texto completo: acesso restrito. p. 437-441 | pt_BR |
dc.description.abstract | A screening of 500 crude extracts of marine invertebrates against the growth of Mycobacterium tuberculosis H37Rv yielded MeOH extracts of the sponges Aplysina cauliformis and Pachychalina sp. with significant activity. Further bioassay-guided fractionation of both crude extracts led to the isolation of four bromine-containing metabolites. The known (+)-fistularin-3 (1) and 11-deoxyfistularin-3 (2), and the new compound 2-(3-amino-2,4-dibromo-6-hydroxyphenyl)acetic acid (3) were isolated from the sponge A. cauliformis, while the new bromotyrosine-derived 3-(3,5-dibromo-4-methoxyphenyl)-2-methoxy-N-methylpropan-1-ammonium (4) was isolated from Pachychalina sp. Compound 4 exhibited weak antimycobacterial activity while compounds 1 - 3 displayed activity against Mycobacterium tuberculosis H37Rv, with MICs of 7.1, 7.3 and 49 μM, respectively. Compounds 1 and 2 also exhibited low cytotoxicity against J744 macrophages, indicating that both 1 and 2 are interesting leads for the development of new anti-tuberculosis agents. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1055/s-2005-916239 | pt_BR |
dc.subject | Antimycobacterial | pt_BR |
dc.subject | Marine sponge | pt_BR |
dc.subject | Aplysina cauliformis | pt_BR |
dc.subject | Pachychalina sp | pt_BR |
dc.subject | Bromotyrosine-derived alkaloids | pt_BR |
dc.title | Antimycobacterial brominated metabolites from two species of marine sponges | pt_BR |
dc.title.alternative | Planta Medica | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 72, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia)
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