https://repositorio.ufba.br/handle/ri/13790
Tipo: | Artigo de Periódico |
Título: | Potential of KM+ lectin in immunization against Leishmania amazonensis infection |
Título(s) alternativo(s): | Vaccine |
Autor(es): | Teixeira, Clarissa Romero Teixeira, Maria Jania Barral-Netto, Manoel Barral, Aldina Maria Prado Cavassani, Karen A. Gomes, Regis Bernardo Brandim Barreira, Maria Cristina Roque Cavada, Benildo Sousa Silva, João Santana da |
Autor(es): | Teixeira, Clarissa Romero Teixeira, Maria Jania Barral-Netto, Manoel Barral, Aldina Maria Prado Cavassani, Karen A. Gomes, Regis Bernardo Brandim Barreira, Maria Cristina Roque Cavada, Benildo Sousa Silva, João Santana da |
Abstract: | In the present study we evaluated Canavalia brasiliensis (ConBr), Pisum arvense (PAA) and Artocarpus integrifolia (KM+) lectins as immunostimulatory molecules in vaccination against Leishmania amazonensis infection. Although they induced IFN-γ production, the combination of the lectins with SLA antigen did not lead to lesion reduction. However, parasite load was largely reduced in mice immunized with KM+ lectin and SLA. KM+ induced a smaller inflammatory reaction in the air pouch model and was able to inhibit differentiation of dendritic cells (BMDC), but to induce maturation by enhancing the expression of MHC II, CD80 and CD86. These observations indicate the modulatory role of plant lectins in leishmaniasis vaccination may be related to their action on the initial innate response. |
Palavras-chave: | Leishmania Lectin Bone-marrow-derived dendritic cells (BMDC) |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/13790 |
Data do documento: | 2006 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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1-s2.0-S0264410X05012892-main.pdf | 356,26 kB | Adobe PDF | Visualizar/Abrir |
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