Campo DC | Valor | Idioma |
dc.contributor.author | Santos, L. N. | - |
dc.contributor.author | Gallo, M. B. C. | - |
dc.contributor.author | Silva, E. S. | - |
dc.contributor.author | Figueiredo, C. A. V. | - |
dc.contributor.author | Cooper, P. J. | - |
dc.contributor.author | Barreto, Mauricio Lima | - |
dc.contributor.author | Loureiro, Sebastião | - |
dc.contributor.author | Carvalho, Lain Carlos Pontes de | - |
dc.contributor.author | Alcântara-Neves, Neuza Maria | - |
dc.creator | Santos, L. N. | - |
dc.creator | Gallo, M. B. C. | - |
dc.creator | Silva, E. S. | - |
dc.creator | Figueiredo, C. A. V. | - |
dc.creator | Cooper, P. J. | - |
dc.creator | Barreto, Mauricio Lima | - |
dc.creator | Loureiro, Sebastião | - |
dc.creator | Carvalho, Lain Carlos Pontes de | - |
dc.creator | Alcântara-Neves, Neuza Maria | - |
dc.date.accessioned | 2013-11-21T20:47:05Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13832 | - |
dc.description | p. 188–193 | pt_BR |
dc.description.abstract | Infections with Trichuris trichiura and other trichurid nematodes
have been reported to display protective effects against
atopy, allergic and autoimmune diseases. The aims of the
present study were to investigate the immunomodulatory
properties of T. trichiura adult worm extract (TtE) and its
fractions (TtEFs) on the production of cytokines by peripheral
blood mononuclear cells and to identify their proteinaceous
components. Fourteen TtEFs were obtained by ion
exchange chromatography and tested for effects on cytokine
production by peripheral blood mononuclear cells. The
molecular constituents of the six most active fractions were
evaluated using nano-LC/mass spectrometry. The homology
between T. trichiura and the related nematode Trichinella
spiralis was used to identify 12 proteins in TtEFs. Among
those identified, fructose biphosphate aldolase, a homologue
of macrophage migration inhibitory factor and heat-shock
protein 70 may contribute to the immunomodulatory effects
of TtEFs. The identification of such proteins could lead to
the development of novel drugs for the therapy of allergic
and other inflammatory diseases. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Parasite Immunology | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://onlinelibrary.wiley.com/doi/10.1111/pim.12025/pdf | pt_BR |
dc.subject | Cytokine | pt_BR |
dc.subject | Immunoregulation | pt_BR |
dc.subject | Peripheral blood mononuclear cells | pt_BR |
dc.subject | Proteomics | pt_BR |
dc.subject | Trichuris spp | pt_BR |
dc.title | A proteomic approach to identify proteins from Trichuris trichiura extract with immunomodulatory effects | pt_BR |
dc.title.alternative | Parasite Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 35, n. 5-6 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
|