Campo DC | Valor | Idioma |
dc.contributor.author | Gadelha, Sandra Rocha | - |
dc.contributor.author | Alcântara, Luiz Carlos Júnior | - |
dc.contributor.author | Costa, Gisele Calazans | - |
dc.contributor.author | Acosta, Angelina Xavier | - |
dc.contributor.author | Rios, Domingos | - |
dc.contributor.author | Kashima, Simone | - |
dc.contributor.author | Covas, Dimas Tadeu | - |
dc.contributor.author | Castro, Bernardo Galvão | - |
dc.creator | Gadelha, Sandra Rocha | - |
dc.creator | Alcântara, Luiz Carlos Júnior | - |
dc.creator | Costa, Gisele Calazans | - |
dc.creator | Acosta, Angelina Xavier | - |
dc.creator | Rios, Domingos | - |
dc.creator | Kashima, Simone | - |
dc.creator | Covas, Dimas Tadeu | - |
dc.creator | Castro, Bernardo Galvão | - |
dc.date.accessioned | 2013-11-22T11:59:51Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13834 | - |
dc.description | Texto completo: acesso restrito. p. 2141-2146 | pt_BR |
dc.description.abstract | HTLV-1 is the etiologic agent of ATL and HAM/TSP. The majority of HTLV-1-infected individuals remain asymptomatic, indicating that the infection alone is not sufficient to cause the diseases. It has been reported that cytokine gene polymorphisms, including polymorphisms at IL-6 and IL-10 gene, might be important. We analyzed SNP in the promoter region of the IL-6: −174, −572, −597, and −634 positions, and IL-10: −592 position to evaluate the role of these polymorphisms in the HAM/TSP pathogenesis in 133 HTLV-1 infected individuals and in 100 healthy individuals from Salvador, Bahia, Brazil. The −634C allele frequencies were higher among HAM/TSP patients (21.2%) than among oligosymptomatic (6.5%; P = 0.038) and asymptomatic (9.5%; P = 0.025) subjects. Similarly, the −174G allele frequencies were higher in HAM/TSP patients than in oligosymptomatic patients (P = 0.02). Moreover, the −634GC/−174GG genotype combination was identified at a higher frequency (38.5%) in the HAM/TSP patients than in subjects with other clinical status (8.7%; P = 0.016 for oligosymptomatic and 15.5%, P = 0.012 for asymptomatic patients). However, the multivariate logistic regression including the genotypes of the three studied loci showed that only −634 C IL-6 carriers remain as significant and independent TSP/HAM predictor (odds ratio [OR] = 5.31; 95% [CI] = 1.60–17.56; P = 0.006). We suggest that −634 G C in IL-6 could contribute to HAM/TSP development and that identification of the collective influence of several cytokine polymorphisms, their prevalence, and their interaction could help to better understand this disease. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1002/jmv.21341 | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Interleukin-6 | pt_BR |
dc.subject | Interleukin-10 | pt_BR |
dc.subject | Polymorphisms | pt_BR |
dc.subject | Brazilian populations | pt_BR |
dc.title | Correlation between polymorphisms at interleukin-6 but not at interleukin-10 promoter and the risk of human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis in Brazilian individuals | pt_BR |
dc.title.alternative | Journal of Medical Virology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 80, n. 12 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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