Campo DC | Valor | Idioma |
dc.contributor.author | Leoratti, Fabiana M. S. | - |
dc.contributor.author | Farias, Lilian | - |
dc.contributor.author | Alves, Fabiana P. | - |
dc.contributor.author | Suarez Mútis, Martha C. | - |
dc.contributor.author | Coura, José R. | - |
dc.contributor.author | Kalil, Jorge | - |
dc.contributor.author | Camargo, Erney Plessmann | - |
dc.contributor.author | Moraes, Sandra L | - |
dc.contributor.author | Ramasawmy, Rajendranath | - |
dc.creator | Leoratti, Fabiana M. S. | - |
dc.creator | Farias, Lilian | - |
dc.creator | Alves, Fabiana P. | - |
dc.creator | Suarez Mútis, Martha C. | - |
dc.creator | Coura, José R. | - |
dc.creator | Kalil, Jorge | - |
dc.creator | Camargo, Erney Plessmann | - |
dc.creator | Moraes, Sandra L | - |
dc.creator | Ramasawmy, Rajendranath | - |
dc.date.accessioned | 2013-11-26T12:56:08Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13889 | - |
dc.description | Texto completo: acesso restrito. p. 772-780 | pt_BR |
dc.description.abstract | Background. Malaria is one of the most significant infectious diseases in the world and is responsible for a large proportion of infant deaths. Toll-like receptors (TLRs), key components of innate immunity, are central to countering infection. Variants in the TLR-signaling pathway are associated with susceptibility to infectious diseases.
Methods. We genotyped single nucleotide polymorphisms (SNPs) of the genes associated with the TLR-signaling pathway in patients with mild malaria and individuals with asymptomatic Plasmodium infections by means of polymerase chain reaction.
Results. Genotype distributions for the TLR-1 I602S differed significantly between patients with mild malaria and persons with asymptomatic infection. The TLR-1 602S allele was associated with an odds ratio (OR) of 2.2 (P = .003; Pcorrected = .015) for malaria among patients with mild malaria due to any Plasmodium species and 2.1 (P = .015; Pcorrected = .75) among patients with mild malaria due to Plasmodium falciparum only. The TLR-6 S249P SNP showed an excess of homozygotes for the TLR-6 249P allele in asymptomatic persons, compared with patients with mild malaria due to any Plasmodium species (OR 2.1; 95% confidence interval [CI], 1.1–4.2; P = .01; Pcorrected = .05), suggesting that the TLR-6 249S allele may be a risk factor for malaria (OR, 2.0; 95% CI, 1.1–3.7; P = 0.01; Pcorrected = .05). The TLR-9 -1486C allele showed a strong association with high parasitemia (P < .001).
Conclusions. Our findings indicate that the TLR-1 and TLR-6 variants are significantly associated with mild malaria, whereas the TLR-9-1486C/T variants are associated with high parasitemia. These discoveries may bring additional understanding to the pathogenesis of malaria. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1086/590440 | pt_BR |
dc.title | Variants in the toll-like receptor signaling pathway and clinical outcomes of malaria | pt_BR |
dc.title.alternative | Journal of Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 198, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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