Campo DC | Valor | Idioma |
dc.contributor.author | Rodriguez, Tânia Tavares | - |
dc.contributor.author | Biscarde, Eduardo Ferreira da Silva | - |
dc.contributor.author | Muniz, Relva de Freitas Diniz Goncalves | - |
dc.contributor.author | Amoedo, Maurício Kauark | - |
dc.contributor.author | Ramalho, Maria José Pedreira | - |
dc.creator | Rodriguez, Tânia Tavares | - |
dc.creator | Biscarde, Eduardo Ferreira da Silva | - |
dc.creator | Muniz, Relva de Freitas Diniz Goncalves | - |
dc.creator | Amoedo, Maurício Kauark | - |
dc.creator | Ramalho, Maria José Pedreira | - |
dc.date.accessioned | 2013-11-26T12:59:53Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1073-2322 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13895 | - |
dc.description | Texto completo: acesso restrito. p. 448-452 | pt_BR |
dc.description.abstract | The identification of nitric oxide (NO) within the hypothalamus and pituitary gland has suggested its role as modulator of the activity on hypothalamic-pituitary axis. Hypothalamic NO synthase (NOS) is known to be regulated by thyroid hormones. We investigated the effects of previous injection of N[omega pi]-nitro-L-arginine methyl ester (L-NAME), a NOS inhibitor, and L-arginine (L-Arg), the substrate for NO synthesis, on prolactin (PRL) secretion, through the lipopolysaccharide (LPS)-induced inflammatory response in thyroidectomized (TX) rats. TX or sham-operated (N) rats were intraperitoneally (i.p.) injected with L-NAME (10 mg kg-1) or L-Arg (200 mg kg-1) or the same volume of vehicle (saline solution) 30 min before endotoxemia-induction with LPS at 250 µg (100 g body weight)-1, i.p.. In N rats, NO increased PRL release in response to endotoxemia, whereas in hypothyroid rats, NO appeared to have the opposite effect. Our data support the hypothesis that NO exerts a modulatory influence on PRL secretion after LPS-induced inflammatory response. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Lipopolysaccharide | pt_BR |
dc.subject | L-NAME | pt_BR |
dc.subject | L-arginine | pt_BR |
dc.subject | Hyroidectomy | pt_BR |
dc.subject | Endotoxemia | pt_BR |
dc.subject | Prolactin | pt_BR |
dc.title | Prolactin secretion in hypothyroid endotoxemic rats: involvement of l-arginine and Nitric Oxide synthase | pt_BR |
dc.title.alternative | Shock | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 23, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
|