Campo DC | Valor | Idioma |
dc.contributor.author | Batista, Ronan | - |
dc.contributor.author | García, Pablo A. | - |
dc.contributor.author | Castro, María Angeles | - |
dc.contributor.author | Corral, José M. Miguel del | - |
dc.contributor.author | Speziali, Nivaldo L. | - |
dc.contributor.author | Varotti, Fernando de P. | - |
dc.contributor.author | Paula, Renata C. de | - |
dc.contributor.author | García-Fernández, Luis F. | - |
dc.contributor.author | Francesch, Andrés | - |
dc.contributor.author | Feliciano, Arturo San | - |
dc.contributor.author | Oliveira, Alaíde B. de | - |
dc.creator | Batista, Ronan | - |
dc.creator | García, Pablo A. | - |
dc.creator | Castro, María Angeles | - |
dc.creator | Corral, José M. Miguel del | - |
dc.creator | Speziali, Nivaldo L. | - |
dc.creator | Varotti, Fernando de P. | - |
dc.creator | Paula, Renata C. de | - |
dc.creator | García-Fernández, Luis F. | - |
dc.creator | Francesch, Andrés | - |
dc.creator | Feliciano, Arturo San | - |
dc.creator | Oliveira, Alaíde B. de | - |
dc.date.accessioned | 2013-11-27T19:37:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0223-5234 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/13983 | - |
dc.description | p. 168-176 | pt_BR |
dc.description.abstract | This paper reports on the syntheses and spectrometric characterisation of eleven novel ent-kaurane
diterpenoids, including a complete set of 1H, 13C NMR and crystallographic data for two novel entkaurane
diepoxides. Moreover, the antineoplastic cytotoxicity for kaurenoic acid and the majority of entkaurane
derivatives were assessed in vitro against a panel of fourteen cancer cell lines, of which allylic
alcohols were shown to be the most active compounds. The good in vitro antimalarial activity and the
higher selectivity index values observed for some ent-kaurane epoxides against the chloroquine-resistant
W2 clone of Plasmodium falciparum indicate that this class of natural products may provide new hits for
the development of antimalarial drugs. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | European Journal of Medicinal Chemistry | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://www.sciencedirect.com/science/article/pii/S0223523412007325 | pt_BR |
dc.subject | Wedelia paludosa D.C. | pt_BR |
dc.subject | Ent-Kaurane derivatives | pt_BR |
dc.subject | In vitro antimalarial activity | pt_BR |
dc.subject | Plasmodium falciparum | pt_BR |
dc.subject | Antineoplastic activity | pt_BR |
dc.title | Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives | pt_BR |
dc.title.alternative | European Journal of Medicinal Chemistry | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v. 62 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Química)
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