https://repositorio.ufba.br/handle/ri/14088
Tipo: | Artigo de Periódico |
Título: | Sesquiterpene lactone from Wunderlichia crulsiana inhibits the respiratory burst of leukocytes triggered by distinct biochemical pathways |
Título(s) alternativo(s): | Life Sciences |
Autor(es): | Roque, Nídia Franca Nuñez, Cecilia Veronica Zacheu, Fabı́ola Maria Pinto, Ernani Colepicolo, Pio Brigagão, Maı́sa Ribeiro Pereira Lima |
Autor(es): | Roque, Nídia Franca Nuñez, Cecilia Veronica Zacheu, Fabı́ola Maria Pinto, Ernani Colepicolo, Pio Brigagão, Maı́sa Ribeiro Pereira Lima |
Abstract: | The sesquiterpene lactone tubiferin was chemically purified from the brazilian native plant Wunderlichia crulsiana and identified by NMR and GC/MS data. Its ability to inhibit the respiratory burst of peritoneal inflammatory polymorphonuclear leukocytes (PMN) stimulated upon addition of phorbol miristate acetate (PMA), opsonized zymosan (OZ), and N-formyl-methionyl-leucyl-phenylalanine (fMLP) was evaluated. The tubiferin inhibition was more pronounced when PMN were stimulated through the protein kinase C pathway (PMA) compared to the alternative complement pathway (OZ). The inhibition when PMN were triggered by a chemoatractant stimulus (fMLP) was similar to that achieved with OZ-stimulated phagocytes. Tubiferin showed dose-dependent effects on the PMN respiratory burst triggered by the three different substances, and also decreased substancially the carrageenan-induced mice paw edema. |
Palavras-chave: | Anti-inflammatory Tubiferin 13C NMR data Sesquiterpene lactone Superoxide anion Polymorphonuclear leukocyte |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/14088 |
Data do documento: | 2003 |
Aparece nas coleções: | Artigo Publicado em Periódico (Química) |
Arquivo | Descrição | Tamanho | Formato | |
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Nídia Franca Roque.pdf | 174,43 kB | Adobe PDF | Visualizar/Abrir |
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