Campo DC | Valor | Idioma |
dc.contributor.author | Xia, Tianli | - |
dc.contributor.author | O'Hara, Andrea | - |
dc.contributor.author | Araújo, Iguaracyra Barreto de Oliveira | - |
dc.contributor.author | Barreto, José Henrique Silva | - |
dc.contributor.author | Carvalho, Eny | - |
dc.contributor.author | Sapucaia, Jose Bahia | - |
dc.contributor.author | Luz, Estela | - |
dc.contributor.author | Pedroso, Celia | - |
dc.contributor.author | Brites, Carlos | - |
dc.contributor.author | Ramos, Juan Carlos | - |
dc.contributor.author | Manrique, Michele | - |
dc.contributor.author | Toomey, Ngoc L. | - |
dc.contributor.author | Dittmer, Dirk P. | - |
dc.contributor.author | Harrington Junior, William J. | - |
dc.creator | Xia, Tianli | - |
dc.creator | O'Hara, Andrea | - |
dc.creator | Araújo, Iguaracyra Barreto de Oliveira | - |
dc.creator | Barreto, José Henrique Silva | - |
dc.creator | Carvalho, Eny | - |
dc.creator | Sapucaia, Jose Bahia | - |
dc.creator | Luz, Estela | - |
dc.creator | Pedroso, Celia | - |
dc.creator | Brites, Carlos | - |
dc.creator | Ramos, Juan Carlos | - |
dc.creator | Manrique, Michele | - |
dc.creator | Toomey, Ngoc L. | - |
dc.creator | Dittmer, Dirk P. | - |
dc.creator | Harrington Junior, William J. | - |
dc.date.accessioned | 2014-01-06T15:28:07Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14272 | - |
dc.description | Texto completo: acesso restrito. p. 1436-1442 | pt_BR |
dc.description.abstract | EBV-encoded microRNAs (miRNAs) have been identified and their functions are being studied. The expression pattern of these miRNAs in clinical samples of EBV-associated non–Hodgkin's lymphomas is unknown. We analyzed five primary “endemic” pediatric Burkitt's lymphomas (BL), two acquired immunodeficiency syndrome (AIDS)-related type I latency BL lines, a type III latency line, three EBV+ primary effusion lymphomas (PEL), and three AIDS-related diffuse large B-cell lymphomas (DLBCL) for expression of EBV-encoded miRNAs. A markedly elevated expression of miRNA BHRF1-3 in type III relative to its parental type I BL line was found. Primary unmanipulated type I BLs and EBV+ PELs expressed high levels of BART2 miRNA, whereas DLBCLs expressed both BART2 and BHRF1-3 species. BHRF1-3 miRNA expression inversely correlated with levels of a putative cellular target, the IFN-inducible T-cell attracting chemokine CXCL-11/I-TAC, and suppression of this factor was reversed by transfection of an antisense oligo to the EBV miRNA BHRF1-3. EBV-encoded miRNAs are expressed in primary lymphomas classically linked to the virus and are associated with the viral latency status. Targeted suppression of CXCL-11/I-TAC by a viral-encoded miRNA may serve as an immunomodulatory mechanism in these tumors. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1158/0008-5472.CAN-07-5126 | pt_BR |
dc.subject | Lymphoma | pt_BR |
dc.subject | EBV | pt_BR |
dc.subject | MicroRNA | pt_BR |
dc.subject | Latency | pt_BR |
dc.subject | Burkitt's | pt_BR |
dc.title | EBV microRNAs in primary lymphomas and targeting of CXCL-11 by ebv-mir-BHRF1-3 | pt_BR |
dc.title.alternative | Cancer Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 68, n. 5 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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