Campo DC | Valor | Idioma |
dc.contributor.author | Gonçalves, Marilda S. | - |
dc.contributor.author | Ozelo, Margareth C. | - |
dc.contributor.author | Costa, Devanira S. P. | - |
dc.contributor.author | Siqueira, Lucia H. | - |
dc.contributor.author | Machado, Tania M. F. | - |
dc.contributor.author | Castro, Vagner | - |
dc.contributor.author | Menezes, Raimundo C. | - |
dc.contributor.author | Soares, Manoel C. P. | - |
dc.contributor.author | Annichino-Bizzacchi, Joyce Maria | - |
dc.contributor.author | Costa, Fernando Ferreira | - |
dc.contributor.author | Arruda, Valder Roberval | - |
dc.creator | Gonçalves, Marilda S. | - |
dc.creator | Ozelo, Margareth C. | - |
dc.creator | Costa, Devanira S. P. | - |
dc.creator | Siqueira, Lucia H. | - |
dc.creator | Machado, Tania M. F. | - |
dc.creator | Castro, Vagner | - |
dc.creator | Menezes, Raimundo C. | - |
dc.creator | Soares, Manoel C. P. | - |
dc.creator | Annichino-Bizzacchi, Joyce Maria | - |
dc.creator | Costa, Fernando Ferreira | - |
dc.creator | Arruda, Valder Roberval | - |
dc.date.accessioned | 2014-01-07T13:08:26Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0361-8609 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14277 | - |
dc.description | Texto completo: acesso restrito. p. 107–116 | pt_BR |
dc.description.abstract | Platelet membrane glycoprotein (GP) Ibα is a critical component of platelet adhesion complex to subendothelium structures following tissue injury or pathological surfaces, such as atherosclerotic plaques. Polymorphisms of the GPIbα gene have been associated with a high risk for occlusive vascular disease, and its distribution varies considerably among distinct populations. These polymorphisms comprise the human platelet antigen (HPA)-2 system, the −5C/T dimorphism of the Kozak sequence, and the variable number of tandem 39-bp repeats (VNTR). Here we report the prevalence of the GPIbα gene polymorphisms among Brazilians, a highly ethnically diverse population. We analyzed 492 subjects of European, African, or Indigenous origin. It was possible to determine ten distinct haplotypes. The most common (∽40%) haplotype was the Kozak-TT/HPA-2aa/VNTR-CC for both Caucasian and African descent. However, among Indigenous, Kozak-TT/HPA-2aa/VNTR-CC and Kozak-TC/HPA-2aa/VNTR-CC were equally present. Although a strong linkage disequilibrium between VNTR and HPA-2 polymorphism had also been observed, here we determined incomplete linkage disequilibrium in 10% of subjects from all ethnic groups. VNTR-E, a rare variant lacking the 39-bp repeat, was identified in two unrelated subjects, and functional platelet studies revealed no abnormalities. The VNTR-A allele, the largest variant containing four copies of the repeats, was not identified in this population. However, homozygosity for the VNTR-A allele (Kozak-TT/HPA-2aa/VNTR-AA) was determined in two distinct species of nonhuman primates. These results suggest a greater complex evolutionary mechanism in the macroglycoprotein region of the GPIbα gene and may be useful in the design of gene–disease association studies for vascular disease. Am. J. Hematol. 77:107–116, 2004. © 2004 Wiley-Liss, Inc. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1002/ajh.20148 | pt_BR |
dc.subject | Glycoprotein Ib alpha | pt_BR |
dc.subject | Polymorphism | pt_BR |
dc.subject | Platelet | pt_BR |
dc.subject | Genetic diversity | pt_BR |
dc.title | Genetic variability of platelet glycoprotein Ibα gene | pt_BR |
dc.title.alternative | American Journal of Hematology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 77, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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