Campo DC | Valor | Idioma |
dc.contributor.author | Brandão, Flávia R. | - |
dc.contributor.author | Vicente, Eliezer J. | - |
dc.contributor.author | Daltro, Carla Hilário da Cunha | - |
dc.contributor.author | Sacramento, Marisa | - |
dc.contributor.author | Moreira, Agnaluce | - |
dc.contributor.author | Adan, Luís Fernando Fernandes | - |
dc.creator | Brandão, Flávia R. | - |
dc.creator | Vicente, Eliezer J. | - |
dc.creator | Daltro, Carla Hilário da Cunha | - |
dc.creator | Sacramento, Marisa | - |
dc.creator | Moreira, Agnaluce | - |
dc.creator | Adan, Luís Fernando Fernandes | - |
dc.date.accessioned | 2014-01-10T16:18:13Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14312 | - |
dc.description | Texto completo: acesso restrito. p. 334-339 | pt_BR |
dc.description.abstract | This cross-sectional study analyzed bone mineral density (BMD) in children and adolescents with type 1 diabetes mellitus (DM1) and its relationship with metabolic control, duration of disease and bone markers.
Methods: Forty-four children and adolescents with DM1 (age 8.8 ± 4.4 years, disease duration 6.6 ± 3.9 years) and 22 healthy children were assessed for BMD of the lumbar spine (L1–L4) by dual energy X-ray absorptiometry; osteocalcin (OC) and carboxy-terminal telopeptide (CTX) were measured in the study group.
Results: The BMD was similar in subjects with (−1.15 ± 1.2 S.D.) and without DM1 (−0.85 ± 0.88 S.D., p = 0.25). After adjustment for weight, height and pubertal development, the BMD was <−2.0 S.D. in only two diabetic patients (4.5%). Bone area (BA) was inversely correlated with the duration of diabetes (p = 0.03) and HbA1c (p = 0.02). In girls, who presented a worse HbA1c than boys (p < 0.01), BMD was inversely correlated with HbA1c (p = 0.05). OC and CTX levels were higher in boys (p < 0.01) and both inversely correlated with pubertal development (p = 0.01), but not with BMD.
Conclusions: Children and adolescents with DM1 have normal bone mass in the lumbar spine. However, longer diabetes duration and poor metabolic control may have a negative impact on bone mass, requiring further investigation through longitudinal studies. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.diabres.2007.04.009 | pt_BR |
dc.subject | Bone mineral density | pt_BR |
dc.subject | Type 1 diabetes mellitus | pt_BR |
dc.subject | Osteopenia | pt_BR |
dc.subject | Metabolic control | pt_BR |
dc.subject | Bone markers | pt_BR |
dc.title | Bone metabolism is linked to disease duration and metabolic control in type 1 diabetes mellitus | pt_BR |
dc.title.alternative | Diabetes Research and Clinical Practice | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 78, n. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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