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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/14640
Tipo: Artigo de Periódico
Título: Infrared laser light further improves bone healing when associated with bone morphogenetic proteins and guided bone regeneration: an in vivo study in a rodent model
Título(s) alternativo(s): Photomedicine and Laser Surgery
Autor(es): Pinheiro, Antonio Luiz Barbosa
Gerbi, Marleny E. Martinez
Ponzi, Elizabeth Arruda Carneiro
Marques, Aparecida M. C.
Carvalho, Carolina Montagn de
Santos, Rafael de Carneiro
Oliveira, Priscila Chagas
Noia, Manuela Pimentel
Autor(es): Pinheiro, Antonio Luiz Barbosa
Gerbi, Marleny E. Martinez
Ponzi, Elizabeth Arruda Carneiro
Marques, Aparecida M. C.
Carvalho, Carolina Montagn de
Santos, Rafael de Carneiro
Oliveira, Priscila Chagas
Noia, Manuela Pimentel
Abstract: Objective: This study assessed histologically the effect of laser photobiomodulation on the repair of surgical defects created in the femurs of Wistar rats treated or not treated with bone morphogenetic proteins (BMPs) and organic bovine bone graft. Background Data: This paper is part of an ongoing series of works in which biomaterials and/or guided bone regeneration (GBR) are used in association with laser photobiomodulation. Several previous reports from our group have shown that the use of laser photobiomodulation improves the treatment of bone defects. Materials and Methods: Forty-eight adult male Wistar rats were divided into four randomized groups: group 1 (controls, n = 12); group 2 (laser photobiomodulation, n = 12); group 3 (BMPs + organic bovine bone graft + GBR, n = 12); and group 4 (BMPs + organic bovine bone graft + GBR + laser photobiomodulation, n = 12). The irradiated groups received seven irradiations every 48 h, the first immediately after the surgical procedure. Laser photobiomodulation (830 nm, 40 mW, CW, 0.6 mm) consisted of a total of 16 J/cm2 per session at four points (4 J/cm2 each) equally spaced around the periphery of the defect. The animals were sacrificed after 15, 21, and 30 d, and the specimens were routinely embedded in wax and stained with hematoxylin and eosin and Sirius red stains and analyzed under light microscopy. Results: The results showed histological evidence of increased deposition of collagen fibers (at 15 and 21 d), as well as an increased amount of well-organized bone trabeculi at the end of the experimental period (30 d) in irradiated animals compared to non-irradiated controls. Conclusion: We concluded that the use of laser photobiomodulation in association with BMPs, organic bovine bone grafts, and GBR increases the positive biomodulating effects of laser energy.
Palavras-chave: Photobiomodulation
Rats
Morphogenetic proteins
Tipo de Acesso: Acesso Aberto
URI: http://repositorio.ufba.br/ri/handle/ri/14640
Data do documento: 2008
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Odontologia)

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