Campo DC | Valor | Idioma |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Muniz, André Luís Nunes | - |
dc.contributor.author | Luna, Tania | - |
dc.contributor.author | Nascimento, Márcia C. | - |
dc.contributor.author | Guerreiro, Jaqueline B. | - |
dc.contributor.author | OliveiraFilho, Jamary | - |
dc.contributor.author | Morgan, Daniel J. | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Muniz, André Luís Nunes | - |
dc.creator | Luna, Tania | - |
dc.creator | Nascimento, Márcia C. | - |
dc.creator | Guerreiro, Jaqueline B. | - |
dc.creator | OliveiraFilho, Jamary | - |
dc.creator | Morgan, Daniel J. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2014-03-13T18:22:22Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1021-7401 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14746 | - |
dc.description | Texto completo: acesso restrito. p. 145–151 | pt_BR |
dc.description.abstract | Objective: Human T lymphotropic virus-type 1 (HTLV-1) activates the immune system leading to a persistent and exacerbated T-cell response with increased production of IFN-γ and TNF-α. Overproduction of pro-inflammatory cytokines is correlated with the development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), although some HTLV-1 carriers also show high levels of these cytokines. In this study, the ability of regulatory cytokines and cytokine antagonists to inhibit spontaneous IFN-γ production was investigated. Method: IFN-γ levels were measured by ELISA before and after addition of cytokines or anti-cytokines. Results: Addition of IL-10 significantly reduced spontaneous IFN-γ synthesis in cell cultures from HTLV-1 carriers, while no differences were observed in HAM/TSP patients. There was also a tendency to decreased IFN-γ levels in cell cultures from HTLV-1 carriers with exogenous addition of TGF-β. In paired analysis, neutralization of IL-2 significantly decreased IFN-γ production in HTLV-1 carriers but not in HAM/TSP patients. Neutralization of IL-15 was less effective than neutralization of IL-2 in modulating IFN-γ production. In HTLV-1 carriers, anti-IL-2 and simultaneous addition of anti-IL-2 and anti-IL-15 decreased IFN-γ synthesis by 46 and 64%, respectively, whereas in patients with HAM/TSP simultaneous neutralization of both anti-cytokines only decrease IFN-γ levels by 27%. Conclusions: Although a large proportion of HTLV-1 carriers produced high levels of pro-inflammatory cytokines similar to those observed in HAM/TSP patients, immune response can be downregulated by cytokines or cytokine antagonists in most HTLV-1 carriers. This modulation can be an important step in the prevention of tissue damage and progression from the HTLV-1 carrier state to HAM/TSP. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1159/000097259 | pt_BR |
dc.subject | Antagonists | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Interferon-γ | pt_BR |
dc.subject | Myelopathy | pt_BR |
dc.subject | T cell responses | pt_BR |
dc.title | Modulation of T cell responses in HTLV-1 carriers and in patients with myelopathy associated with HTLV-1 | pt_BR |
dc.title.alternative | Neuroimmunomodulation | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 13, n. 3 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
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