Campo DC | Valor | Idioma |
dc.contributor.author | Carvalho Filho, Paulo Cirino de | - |
dc.contributor.author | Trindade, Soraya Castro | - |
dc.contributor.author | Olczak, Teresa | - |
dc.contributor.author | Sampaio, Geraldo P. | - |
dc.contributor.author | Oliveira Neto, Milton G. | - |
dc.contributor.author | Santos, Heidiane Alves dos | - |
dc.contributor.author | Pereira, Bianca F. P. | - |
dc.contributor.author | Costa, Lilia Moura | - |
dc.contributor.author | Xavier, Márcia Tosta | - |
dc.contributor.author | Nascimento, Roberto José Meyer | - |
dc.creator | Carvalho Filho, Paulo Cirino de | - |
dc.creator | Trindade, Soraya Castro | - |
dc.creator | Olczak, Teresa | - |
dc.creator | Sampaio, Geraldo P. | - |
dc.creator | Oliveira Neto, Milton G. | - |
dc.creator | Santos, Heidiane Alves dos | - |
dc.creator | Pereira, Bianca F. P. | - |
dc.creator | Costa, Lilia Moura | - |
dc.creator | Xavier, Márcia Tosta | - |
dc.creator | Nascimento, Roberto José Meyer | - |
dc.date.accessioned | 2014-05-05T13:41:28Z | - |
dc.date.available | 2014-05-05T13:41:28Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1471-2180 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/14902 | - |
dc.description | p. 1-6 | pt_BR |
dc.description.abstract | Background: Apoptosis is a highly controlled process of cell death that can be induced by periodontopathogens. The present study aimed to investigate the expression of Fas and Bcl-2 proteins by CD3+ T cells in vitro under stimulation by total Porphyromonas gingivalis antigens and purified recombinant P. gingivalis HmuY protein.
Results: CD3+ T cells derived from CP patients and stimulated with HmuY expressed higher levels of Bcl-2 compared to identical cells stimulated with P. gingivalis crude extract or cells derived from NP control subjects (p = 0.043).
Conclusion: The authors hypothesize that P. gingivalis HmuY plays a role in the pathogenesis of chronic periodontitis, possibly by reducing or delaying apoptosis in T cells through a pathway involving the Bcl-2 protein. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1186/1471-2180-13-206 | pt_BR |
dc.subject | Porphyromonas gingivalis | pt_BR |
dc.subject | HmuY | pt_BR |
dc.subject | Bcl-2 | pt_BR |
dc.subject | Fas | pt_BR |
dc.subject | Apoptosis | pt_BR |
dc.title | Porphyromonas gingivalis HmuY stimulates expression of Bcl-2 and Fas by human CD3+ T cells | pt_BR |
dc.title.alternative | BMC Microbiology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 13, n. 1 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico Estrangeiro (ISC)
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