Campo DC | Valor | Idioma |
dc.contributor.author | Cardoso, Luciana Santos | - |
dc.contributor.author | Barreto, Andréia de Sousa Rocha | - |
dc.contributor.author | Fernandes, Jamille Souza | - |
dc.contributor.author | Oliveira, Ricardo Riccio | - |
dc.contributor.author | Souza, Robson da Paixão de | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Araujo, Maria Ilma Andrade Santos | - |
dc.creator | Cardoso, Luciana Santos | - |
dc.creator | Barreto, Andréia de Sousa Rocha | - |
dc.creator | Fernandes, Jamille Souza | - |
dc.creator | Oliveira, Ricardo Riccio | - |
dc.creator | Souza, Robson da Paixão de | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Araujo, Maria Ilma Andrade Santos | - |
dc.date.accessioned | 2014-09-09T14:48:03Z | - |
dc.date.available | 2014-09-09T14:48:03Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 1740-2522 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/15885 | - |
dc.description | p. 1-8 | pt_BR |
dc.description.abstract | The Th2 immune response in chronic schistosomiasis is associated with the development of periportal fibrosis. However, little is known about the phenotype and activation status of T cells in the process. Objective. To evaluate the profile of T cells in schistosomiasis patients with periportal fibrosis. Methods. It was a cross-sectional study, conducted in the village of Agua Preta, Bahia, Brazil, which included 37 subjects with periportal fibrosis determined by ultrasound. Peripheral blood mononuclear cells were obtained by the Ficcol-hypaque gradient and the frequency of T cells expressing the surface markers CD28, CD69, CD25, and CTLA-4 was determined by flow cytometry. Results. The frequency of CD4+CD28+ T lymphocytes was higher in individuals with moderate to severe fibrosis compared to patients with incipient fibrosis. We did not observe any significant difference in the frequency of CD4+ T cells expressing CD69 among groups of individuals. There was also no significant difference in the frequency of CD8+ T cells expressing CD28 or CD69 among the studied groups. Individuals with moderate to severe fibrosis presented a lower frequency of CD8+ T cells, CD4+CD25high T cells, and CD4+CTLA-4+ T cells when compared to patients without fibrosis or incipient fibrosis. The frequency of CD4+CD25low cells did not differ between groups. Conclusion. The high frequency of activated T cells coinciding with a low frequency of putative Treg cells may account for the development of periportal fibrosis in human schistosomiasis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/10.1155/2013/710647 | pt_BR |
dc.title | Impaired lymphocyte profile in schistosomiasis patients with periportal fibrosis | pt_BR |
dc.title.alternative | Clinical and Developmental Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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