https://repositorio.ufba.br/handle/ri/16385
Tipo: | Artigo de Periódico |
Título: | FOXP3 expression in papillary thyroid carcinoma with and without Hashimoto's thyroiditis |
Título(s) alternativo(s): | Jornal Brasileiro de Patologia e Medicina Laboratorial |
Autor(es): | Neves Júnior, Murilo Pedreira Carvalho Filho, Edgar Marcelino de Camandaroba, Marcos Pedro Guedes Mascarenhas, Milena Brachmans Correia, Thaizza Cavalcante Neves, Yuri Costa Sarno |
Autor(es): | Neves Júnior, Murilo Pedreira Carvalho Filho, Edgar Marcelino de Camandaroba, Marcos Pedro Guedes Mascarenhas, Milena Brachmans Correia, Thaizza Cavalcante Neves, Yuri Costa Sarno |
Abstract: | INTRODUCTION: The forkhead box P3 (FOXP3) plays a role in cell development and control. In the presence of abnormal FOXP3 expression, tumor cells may evade the immunosurveillance of lymphoid cells, the first step for the maintenance of cancer cells in the thyroid tissue. OBJECTIVE: To identify the presence of FOXP3 in papillary thyroid carcinoma (PTC) with and without Hashimoto's Thyroiditis (HT). METHODS: We conducted a series study of cases collected from 2000 to 2008, when 1,438 thyroidectomies were performed. We selected those diagnosed with PTC, comprising 466 cases. 30 patients were randomly selected for purposes of immunohistochemistry with antibodies against FOXP3. RESULT: FOXP3 revealed high positivity for PTC and positive immunostaining was present in 21 (72.4%) from all analyzed cases. There was no difference regarding coexistent HT or not. DISCUSSION AND CONCLUSION: In the present study, it was evidenced that the focal or diffuse FOXP3 expression was commonly observed in neoplastic cells from PTC, hence indicating that the assessment of this molecule expression in suspected cases of thyroid cancer may contribute to its diagnosis. |
Palavras-chave: | Thyroiditis Papillary thyroid carcinoma FOXP3 Immunohistochemistry Pathology Hashimoto's thyroiditis |
País: | Brasil |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/16385 |
Data do documento: | 2013 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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10.1590S1676-24442013000400010.pdf | 281,64 kB | Adobe PDF | Visualizar/Abrir |
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