Campo DC | Valor | Idioma |
dc.contributor.author | Lins, Liliane | - |
dc.contributor.author | Carvalho, Victor José Uchoa de | - |
dc.contributor.author | Rego, Filipe Ferreira de Almeida | - |
dc.contributor.author | Azevedo, Rochele | - |
dc.contributor.author | Kashima, Simone | - |
dc.contributor.author | Gallazi, Viviana Nilla Olavarria | - |
dc.contributor.author | Xavier, Márcia Tosta | - |
dc.contributor.author | Castro, Bernardo Galvão | - |
dc.contributor.author | Alcântara, Luiz Carlos Júnior | - |
dc.creator | Lins, Liliane | - |
dc.creator | Carvalho, Victor José Uchoa de | - |
dc.creator | Rego, Filipe Ferreira de Almeida | - |
dc.creator | Azevedo, Rochele | - |
dc.creator | Kashima, Simone | - |
dc.creator | Gallazi, Viviana Nilla Olavarria | - |
dc.creator | Xavier, Márcia Tosta | - |
dc.creator | Castro, Bernardo Galvão | - |
dc.creator | Alcântara, Luiz Carlos Júnior | - |
dc.date.accessioned | 2014-11-14T13:00:07Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 0146-6615 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/16601 | - |
dc.description | Texto completo: acesso restrito. p. 1428–1436 | pt_BR |
dc.description.abstract | Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV-1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV-1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra-host variations from peripheral blood mononuclear cells and saliva cells. It is a cross-sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV-1 positive and 30 were negative. Individuals from the HTLV-1 positive and negative groups had similar mean age and social-economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P < 0.05 were considered statistically significant. HTLV-1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV-1 carriers. The HTLV-1 molecular analysis from PBMC and saliva specimens suggests that HTLV-1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed. | pt_BR |
dc.language.iso | en | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://dx.doi.org/ 10.1002/jmv.23327 | pt_BR |
dc.subject | Oral Health | pt_BR |
dc.subject | Saliva | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.title | Oral health profile in patients infected with HTLV-1: Clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva | pt_BR |
dc.title.alternative | Journal of Medical Virology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 84, n. 9 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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