https://repositorio.ufba.br/handle/ri/17522
Tipo: | Artigo de Periódico |
Título: | Lesion Size Correlates with Leishmania Antigen-Stimulated TNF-Levels in Human Cutaneous Leishmaniasis |
Título(s) alternativo(s): | American Journal of Tropical Medicine and Hygiene |
Autor(es): | Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
Autor(es): | Oliveira, Luiz Fabiano Borges Báfica, Andre Luiz Barbosa Rosato, Andréa Bomura Favali, Cecilia Beatriz Fiuza Costa, Jackson Mauricio Lopes Café, Virginia Barral-Netto, Manoel Barral, Aldina Maria Prado |
Abstract: | Cutaneous leishmaniasis (CL) is a worldwide disease endemic in several regions of the globe. The hallmark of CL is skin ulcers likely driven by efforts of the immune system to control Leishmania growth. Cytokines, such as tumor necrosis factor (TNF) and interferon-gamma can control disease progression in animal models. Nevertheless, the impact of these cytokines in CL ulcer outcome is not well established in humans. In this study, 96 CL patients from an endemic area of Leishmania braziliensis were enrolled for a follow-up study that consisted of clinical and immunological evaluations in a 2-year period. Statistical analysis revealed that healing time (P = 0.029), age (P = 0.002), and TNF levels (P = 0.0002) positively correlate with ulcer size at the time of the first clinical evaluation. Our findings suggest that ulcer size correlates with healing time and TNF levels support the use of TNF inhibitors combined with standard therapy to improve healing in CL patients with severe lesions. |
Palavras-chave: | Leishmania Cytokines Lymphotoxin-alpha |
País: | Brasil |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/17522 |
Data do documento: | 2011 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Fabiano Oliveira.pdf | 471,06 kB | Adobe PDF | Visualizar/Abrir |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.