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dc.contributor.authorPadovani, Juliana Lara-
dc.contributor.authorCorvino, Silvia Maria-
dc.contributor.authorDrexler, Jan Felix-
dc.contributor.authorSilva, Giovanni Faria-
dc.contributor.authorPardini, Maria Inês de Moura Campos-
dc.contributor.authorGrotto, Rejane Maria Tommasini-
dc.creatorPadovani, Juliana Lara-
dc.creatorCorvino, Silvia Maria-
dc.creatorDrexler, Jan Felix-
dc.creatorSilva, Giovanni Faria-
dc.creatorPardini, Maria Inês de Moura Campos-
dc.creatorGrotto, Rejane Maria Tommasini-
dc.date.accessioned2015-05-06T15:24:45Z-
dc.date.available2015-05-06T15:24:45Z-
dc.date.issued2013-
dc.identifier.issn0037-8682-
dc.identifier.urihttp://repositorio.ufba.br/ri/handle/ri/17612-
dc.descriptionp. 154-155pt_BR
dc.description.abstractIntroduction Despite hepatocytes being the target cells of hepatitis C virus (HCV), viral ribonucleic acid RNA has been detected in other cells, including platelets, which have been described as carriers of the virus in the circulation of infected patients. Platelets do not express cluster differentiation 81 CD81, the main receptor for the virus in hepatocytes, although this receptor protein has been found in megakaryocytes. Still, it is not clear if HCV interacts with platelets directly or if this interaction is a consequence of its association with megakaryocytes. The aim of this study was to evaluate the interaction of HCV with platelets from non-infected individuals, after in vitro exposure to the virus. Methods Platelets obtained from 50 blood donors not infected by HCV were incubated in vitro at 37°C for 48h with serum containing 100,000IU∕mL of genotype 1 HCV. After incubation, RNA extracted from the platelets was assayed for the presence of HCV by reverse transcription – polymerase chain reaction RT-PCR. Results After incubation in the presence of virus, all samples of platelets showed HCV RNA. Conclusions The results demonstrate that, in vitro, the virus interacts with platelets despite the absence of the receptor CD81, suggesting that other molecules could be involved in this association.pt_BR
dc.language.isoenpt_BR
dc.rightsAcesso Abertopt_BR
dc.sourcehttp://dx.doi.org/10.1590/0037-8682-1627-2013pt_BR
dc.subjectHCVpt_BR
dc.subjectPlateletspt_BR
dc.subjectCD81pt_BR
dc.titleIn vitro detection of hepatitis C virus in platelets from uninfected individuals exposed to the viruspt_BR
dc.title.alternativeRevista da Sociedade Brasileira de Medicina Tropicalpt_BR
dc.typeArtigo de Periódicopt_BR
dc.identifier.numberv. 46, n. 2pt_BR
dc.publisher.countryBrasilpt_BR
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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