https://repositorio.ufba.br/handle/ri/17845
Tipo: | Artigo de Periódico |
Título: | Impaired T Helper 2 Response to Aeroallergen in Helminth-Infected Patients with Asthma |
Título(s) alternativo(s): | Journal of Infectious Diseases |
Autor(es): | Araujo, Maria Ilma Andrade Santos Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
Autor(es): | Araujo, Maria Ilma Andrade Santos Hoppe, Bradford Medeiros Junior, Manoel Alcântara, Leda Maria Almeida, Maria Cecilia Freitas de Schriefer, Nicolaus Albert Borges Oliveira, Ricardo Riccio Kruschewsky, Ramon de Almeida Figueiredo, Joanemile Pacheco de Cruz Filho, Álvaro Augusto Souza da Carvalho Filho, Edgar Marcelino de |
Abstract: | Helminthic infections have been shown to inhibit allergy skin-prick tests and to modify the course of asthma. We evaluated Dermatophagoides pteronyssinus-specific immune responses in patients with asthma by measuring levels of T helper 2 (Th2) cytokines in peripheral blood mononuclear cell (PBMC) cultures. PBMCs from Schistosoma mansoni-infected patients with asthma living in an area of polyhelminthic endemicity produced lower levels of interleukin (IL)-5 and IL-4 in response to D. pteronyssinus antigen (Ag) 1 than did PBMCs from helminth-free patients with asthma. In contrast, D. pteronyssinus Ag 1-specific production of IL-10 was higher in helminth-infected patients than in helminth-free patients. The addition of recombinant human IL-10 to D. pteronyssinus Ag 1-stimulated cultures of PBMCs from helminth-free patients led to downmodulation of production of IL-5. After helminth-infected patients with asthma received antihelminthic treatment, there was down-modulation of D. pteronyssinus Ag 1-specific production of IL-10 in vitro. S. mansoni-infected patients with asthma produce lower levels of Th2 cytokines than do helminth-free patients with asthma, and this modulation is likely done by IL-10. |
Palavras-chave: | Asthma Interleukin-4 Interleukin-5 Asma Interleucina-4 Th2 Cells Interleucina-5 Células TH2 |
Tipo de Acesso: | Acesso Aberto |
URI: | http://repositorio.ufba.br/ri/handle/ri/17845 |
Data do documento: | 2004 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Edgar M. Carvalho.pdf | 434,55 kB | Adobe PDF | Visualizar/Abrir |
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