Campo DC | Valor | Idioma |
dc.contributor.author | Andrade, Luis Jesuino de Oliveira | - |
dc.contributor.author | Melo, Paulo Roberto Santana de | - |
dc.contributor.author | França, Larissa Santos | - |
dc.contributor.author | França, Luciana Santos | - |
dc.contributor.author | Malta, Ana Micheline Andrade | - |
dc.contributor.author | Paraná, Raymundo | - |
dc.creator | Andrade, Luis Jesuino de Oliveira | - |
dc.creator | Melo, Paulo Roberto Santana de | - |
dc.creator | França, Larissa Santos | - |
dc.creator | França, Luciana Santos | - |
dc.creator | Malta, Ana Micheline Andrade | - |
dc.creator | Paraná, Raymundo | - |
dc.date.accessioned | 2017-06-05T19:17:25Z | - |
dc.date.available | 2017-06-05T19:17:25Z | - |
dc.date.issued | 2011-05 | - |
dc.identifier.citation | R. Ci. med. biol., Salvador, v.10, n.2, p.179-186, mai./ago. 2011 | pt_BR |
dc.identifier.issn | 2236-5222 | - |
dc.identifier.uri | http://repositorio.ufba.br/ri/handle/ri/22806 | - |
dc.description | Key Words: Major histocompatibility complex. Hepatitis C. Interferon-alpha. Thyroid dysfunction. Autoimmunity. | pt_BR |
dc.description.abstract | Abstract
The major histocompatibility complex (MHC) is a multigenice family of receptors which are crucial in antigen presentation,
mediation, and initiation of the cellular immune response. An association exists between certain MHC polymorphisms and
autoimmune thyroid disease in animals and humans. Hepatitis C virus (HCV) infection the treatment of hepatitis C with
interferon- (IFN- )have been shown to be associated with increased incidence of thyroid dysfunction. IFN- has been the
basis for the treatment of HCV infection identified as an immunomodulatory cytokine that induces T-lymphocyte activation
and expression of MHC molecules. It becomes evident therefore that the MHC- class I and MHC- class II antigens are central to
the host immune response and thus are ideal candidate genes to investigate for associations with HCV infection. Autoimmune
thyroid diseases are characterized by increased, rather than decreased expression, of MHC- class II antigen. Furthermore, work
in animals suggests that the increased production of thyroid antibody and expression of MHC- class I and MHC- class II antigen
are associated. This study will approach the relation between MHC and thyroid dysfunction in HCV infection carries. | pt_BR |
dc.language.iso | pt_BR | pt_BR |
dc.publisher | Instituto de Ciências da Saúde/ Universidade Federal da Bahia | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.source | http://www.portalseer.ufba.br/index.php/cmbio/article/view/4825/4173 | pt_BR |
dc.subject | Complexo de histocompatibilidade maior | pt_BR |
dc.subject | Hepatite C | pt_BR |
dc.subject | Interferon-alfa | pt_BR |
dc.subject | Disfunção da tireóide | pt_BR |
dc.subject | Auto-imunidade. | pt_BR |
dc.title | Human major histocompatibility complex and thyroid dysfunction in hepatitis C carries | pt_BR |
dc.title.alternative | Revista de Ciências Médicas e Biológicas | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
dc.identifier.number | v.10, n. 2 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (PPGPIOS)
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