Campo DC | Valor | Idioma |
dc.contributor.author | Veiga, Rafael Valente | - |
dc.contributor.author | Cunha, Sergio Souza da | - |
dc.contributor.author | Dattoli, Vitor Camilo Cavalcante | - |
dc.contributor.author | Cruz Filho, Álvaro Augusto Souza da | - |
dc.contributor.author | Cooper, Phillip J. | - |
dc.contributor.author | Rodrigues, Laura Cunha | - |
dc.contributor.author | Barreto, Mauricio Lima | - |
dc.contributor.author | Neves, Neuza Maria Alcântara | - |
dc.creator | Veiga, Rafael Valente | - |
dc.creator | Cunha, Sergio Souza da | - |
dc.creator | Dattoli, Vitor Camilo Cavalcante | - |
dc.creator | Cruz Filho, Álvaro Augusto Souza da | - |
dc.creator | Cooper, Phillip J. | - |
dc.creator | Rodrigues, Laura Cunha | - |
dc.creator | Barreto, Mauricio Lima | - |
dc.creator | Neves, Neuza Maria Alcântara | - |
dc.date.accessioned | 2011-09-23T13:56:14Z | - |
dc.date.available | 2011-09-23T13:56:14Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1471-2466 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/2838 | - |
dc.description.abstract | Background: The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low in rural populations and some non-affluent countries. An explanation for these trends is that increased exposure to infections may provide protection against the development of allergy. In this work we investigated the
association between exposure to viral infections in children living in urban Brazil and the prevalence of atopy and
asthma. Methods: School age children living in poor neighborhoods in the city of Salvador were studied. Data on asthma
symptoms and relevant risk factors were obtained by questionnaire. Skin prick tests (SPTs) were performed to seven aeroallergens, and specific IgE was measured to four of these. Viral infections were determined by the presence of specific IgG in serum to Herpes simplex (HSV), Herpes zoster (HZV), Epstein-Barr (EBV), and Hepatitis A (HAV) viruses. Results: A total of 644 (49.7%) children had at least one allergen-specific IgE> 0.35 kU/L and 489 (37.7%) had specific IgE> 0.70 kU/L. A total of 391 (30.2%) children were skin test positive (SPT+), and 295 (22.8%) children were asthmatic. The seroprevalence of viral infections was 88.9% for EBV, 55.4% for HSV, 45.5% for VZV and 17.5% for HAV. Negative associations were observed between SPT+ and HSV (OR = 0.64, CI = 0.51, 0.82) and EBV (OR = 0.63,CI = 0.44, 0.89) infections, but no associations were seen between viral infections and the presence of allergenspecific IgE or asthma. Conclusion: These data do not support previous data showing a protective effect of HAV against atopy, but did show inverse associations between SPT+ (but not specific IgE+) and infections with HSV and EBV. These findings
suggest that different viral infections may protect against SPT+ in different settings and may indicate an immunoregulatory role of such infections on immediate ypersensitivity responses. The data provide no support for a protective effect of viral infections against asthma in this population. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | Asthma | pt_BR |
dc.subject | Virus Diseases | pt_BR |
dc.subject | Children | pt_BR |
dc.title | Chronic virus infections supress atopy but not asthma in a set of children from a large Latin American city: a cross-section study | pt_BR |
dc.title.alternative | BMC Pulm Med | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Londres | pt_BR |
dc.identifier.number | v.11, p.3-8, 2011. | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico Estrangeiro (ISC)
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