Soroconversão e Fatores Associados à Cobertura Vacinal para Hepatite B em Crianças e Adolescentes com Diabetes Mellitus Tipo 1

Abstract

Objectives: to evaluate the soroconversion effectiveness after the administration of hepatitis B vaccine in children with type 1 diabetes mellitus (T1DM). Method: a systematic review of the literature where the articles were found in the period between 1982 and 2017, guided by the question: Is the seroconversion to hepatitis B with T1DM effective in children and adolescents? The literature was searched in the Medline, SciELO, Scopus and Science Direct database were consulted. Two evaluators independently searched, selected, extracted the data, and assessed the quality of the studies with coefficient of agreement of Kappa 0.7. The degree of agreement between both reviewers was excellent in all cases. Results: Studies with more than 100 participants were evaluated. The variables studied were the frequency/occurrence of immune responses to the hepatitis B vaccine, administered intradermally to fight the disease, as well as its influence on the prevention of hepatitis B in individuals living with diabetes. The sample size ranged from 41 to 4641 children and adolescents. Conclusions: This review is designed for conversion children, and with an enhanced response for an improved response, adolescents and with an enhanced version for an enhanced response, adolescents, with an enhanced version, for an improved immune response. vaccine against hepatitis B.