Campo DC | Valor | Idioma |
dc.contributor.author | Gattás, G. J. F. | - |
dc.contributor.author | Kato, M. | - |
dc.contributor.author | Vieira, J. A. Soares | - |
dc.contributor.author | Siraque, M. S. | - |
dc.contributor.author | Kohler, P. | - |
dc.contributor.author | Gomes, L. | - |
dc.contributor.author | Rêgo, Marco Antônio Vasconcelos | - |
dc.contributor.author | Bydlowski, S. P. | - |
dc.creator | Gattás, G. J. F. | - |
dc.creator | Kato, M. | - |
dc.creator | Vieira, J. A. Soares | - |
dc.creator | Siraque, M. S. | - |
dc.creator | Kohler, P. | - |
dc.creator | Gomes, L. | - |
dc.creator | Rêgo, Marco Antônio Vasconcelos | - |
dc.creator | Bydlowski, S. P. | - |
dc.date.accessioned | 2011-11-25T12:07:44Z | - |
dc.date.available | 2011-11-25T12:07:44Z | - |
dc.date.issued | 2004 | - |
dc.identifier.issn | 0100-879X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/3874 | - |
dc.description | p. 451-458. | pt_BR |
dc.description.abstract | The distribution of polymorphisms related to glutathione S-transferases
(GST) has been described in different populations, mainly for
white individuals. We evaluated the distribution of GST mu (GSTM1)
and theta (GSTT1) genotypes in 594 individuals, by multiplex PCRbased
methods, using amplification of the exon 7 of CYP1A1 gene as
an internal control. In São Paulo, 233 whites, 87 mulattos, and 137
blacks, all healthy blood-donor volunteers, were tested. In Bahia,
where black and mulatto populations are more numerous, 137 subjects
were evaluated. The frequency of the GSTM1 null genotype was
significantly higher among whites (55.4%) than among mulattos
(41.4%; P = 0.03) and blacks (32.8%; P < 0.0001) from São Paulo, or
Bahian subjects in general (35.7%; P = 0.0003). There was no statistically
different distribution among any non-white groups. The distribution
of GSTT1 null genotype among groups did not differ significantly.
The agreement between self-reported and interviewer classification
of skin color in the Bahian group was low. The interviewer
classification indicated a gradient of distribution of the GSTM1 null
genotype from whites (55.6%) to light mulattos (40.4%), dark mulattos
(32.0%) and blacks (28.6%). However, any information about race
or ethnicity should be considered with caution regarding the bias
introduced by different data collection techniques, specially in countries
where racial admixture is intense, and ethnic definition boundaries
are loose. Because homozygous deletions of GST gene might be
associated with cancer risk, a better understanding of chemical metabolizing
gene distribution can contribute to risk assessment of
humans exposed to environmental carcinogens. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | Glutathione S-transferase mu (GSTM1) | pt_BR |
dc.subject | Glutathione S-transferase theta (GSTT1) | pt_BR |
dc.subject | Enzyme polymorphism | pt_BR |
dc.subject | Population frequency | pt_BR |
dc.subject | Ethnicity | pt_BR |
dc.subject | Brazil | pt_BR |
dc.title | Ethnicity and glutathione S-transferase (GSTM1/GSTT1) polymorphisms in a Brazilian population | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | 37(4) | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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