Campo DC | Valor | Idioma |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Braga, Silvane | - |
dc.contributor.author | Castro, Bernardo Galvão | - |
dc.contributor.author | Neva, Franklin A. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Braga, Silvane | - |
dc.creator | Castro, Bernardo Galvão | - |
dc.creator | Neva, Franklin A. | - |
dc.date.accessioned | 2011-12-13T15:48:38Z | - |
dc.date.available | 2011-12-13T15:48:38Z | - |
dc.date.issued | 2001 | - |
dc.identifier.issn | 1077-945 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/4834 | - |
dc.description | p. 1-6 | pt_BR |
dc.description.abstract | The modulation of the immune response has been used as therapy for clinical disorders
associated with human T-lymphotropic virus type 1 (HTLV-1) infection. In this study, the
cytokine profile was evaluated in 26 asymptomatic HTLV-1 blood donors. Additionally, both the cell responsible for producing interferon-γ (IFN-γ) and the role of exogenous interleukin (IL)-10 in downregulating IFN-γ production were studied. Cytokine levels were determined in supernatants of unstimulated lymphocyte cultures by enzyme-linked immunosorbent assay. The levels of IFN-γ, tumor necrosis factor-α, IL-5, and IL-10 were higher in supernatants of the lymphocyte cultures taken from HTLV-1-infected donors than
in those taken from healthy subjects. Although depletion of CD8+ T cells and natural killer cells did not affect IFN-γ production, depletion of CD4+ T cells significantly decreased IFN-γ production. Furthermore, at a concentration of 2 ng/ml, IL-10 had only a minimum effect on IFN-γ producti on, although at high concentrations (100 ng/ml), IL-10 decreased IFN-γ production by 50% in HTLV-1-infected individuals. These data indicate that both T
helper 1 and T helper 2 cytokines are elevated in HTLV-1 infection and that IL-10 in high concentrations modulates IFN-γ production in these patients. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | Cellular immunity in HTLV-1 | pt_BR |
dc.subject | Cytokines in HTLV-1 | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Immune response in HTLV-1 | pt_BR |
dc.subject | Immunomodulation in HTLV-1 | pt_BR |
dc.title | Cytokine Profile and Immunomodulation in Asymptomatic Human T-Lymphotropic Virus Type 1-Infected Blood Donors | pt_BR |
dc.title.alternative | Journal of acquired immune deficiency syndromes and human retrovirology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | 27(1) | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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