Campo DC | Valor | Idioma |
dc.contributor.author | Fregoneze, Josmara Bartolomei | - |
dc.contributor.author | Oliveira, Elenilda Farias | - |
dc.contributor.author | Ribeiro, Vanessa Fonseca | - |
dc.contributor.author | Ferreira, Hilda Silva | - |
dc.contributor.author | Silva, Emilio Jose de Castro e | - |
dc.creator | Fregoneze, Josmara Bartolomei | - |
dc.creator | Oliveira, Elenilda Farias | - |
dc.creator | Ribeiro, Vanessa Fonseca | - |
dc.creator | Ferreira, Hilda Silva | - |
dc.creator | Silva, Emilio Jose de Castro e | - |
dc.date.accessioned | 2012-01-02T11:53:11Z | - |
dc.date.available | 2012-01-02T11:53:11Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0143-4179 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/4994 | - |
dc.description | p. 219–227 | pt_BR |
dc.description.abstract | The aim of the present work was to investigate the role of brain l, j and d opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central 5-HT3 receptors yields a significant decrease in blood pressure; (2) the blockade of those receptors by a selective antagonist induces an acute hypertensive response; (3) the
pharmacological blockade of central opioid receptors by three different opioid antagonists exhibiting variable degrees of selectivity to l, j and d opioid receptors always suppressed the hypotensive response
induced by central 5-HT3 receptor stimulation; (4) the blockade of opioid receptors by the same opioid antagonists that impaired the hypotensive effect of central 5-HT3 receptor stimulation failed to modify blood pressure in animals not submitted to pharmacological manipulations of central 5-HT3 receptor function. It is shown that a 5-HT3 receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-HT3 receptors exert a tonic inhibitory drive on blood pressure. Furthermore, the data obtained here clearly indicate that the hypotensive response
observed after pharmacological stimulation of central 5-HT3 receptors depends on the functional integrity of brain l, j and d opioid receptors, suggesting that a functional interaction between serotonergic
and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | 5-HT3 receptors | pt_BR |
dc.subject | Opioid receptors | pt_BR |
dc.subject | Blood pressure | pt_BR |
dc.title | Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation | pt_BR |
dc.title.alternative | Neuropeptides | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 45 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
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