Campo DC | Valor | Idioma |
dc.contributor.author | Costa, Lília Ferreira de Moura | - |
dc.contributor.author | Cerqueira, Robson Bahia | - |
dc.contributor.author | Carminati, Renato | - |
dc.contributor.author | Vale, Vera Lúcia Costa | - |
dc.contributor.author | Paule, Bruno Jean Adrien | - |
dc.contributor.author | Portela, Ricardo Wagner Dias | - |
dc.contributor.author | Freire, Songeli Menezes | - |
dc.contributor.author | Nascimento, Ivana Lúcia de Oliveira | - |
dc.contributor.author | Schaer, Robert Eduard | - |
dc.contributor.author | Barreto, Luiz Miguel Santos | - |
dc.contributor.author | Nascimento, Roberto José Meyer | - |
dc.creator | Costa, Lília Ferreira de Moura | - |
dc.creator | Cerqueira, Robson Bahia | - |
dc.creator | Carminati, Renato | - |
dc.creator | Vale, Vera Lúcia Costa | - |
dc.creator | Paule, Bruno Jean Adrien | - |
dc.creator | Portela, Ricardo Wagner Dias | - |
dc.creator | Freire, Songeli Menezes | - |
dc.creator | Nascimento, Ivana Lúcia de Oliveira | - |
dc.creator | Schaer, Robert Eduard | - |
dc.creator | Barreto, Luiz Miguel Santos | - |
dc.creator | Nascimento, Roberto José Meyer | - |
dc.date.accessioned | 2012-01-25T12:14:46Z | - |
dc.date.available | 2012-01-25T12:14:46Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 0165-2427 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5246 | - |
dc.description | p.131–141 | pt_BR |
dc.description.abstract | Corynebacterium pseudotuberculosis is the etiologic agent of caseous lymphadenitis, a disease that affects goats and sheep, and
can cause severe economic losses. In this study, four different antigenic extracts were obtained from the attenuated strain T1, which was isolated in the state of Bahia (Brazil). Forty-four Caninde´ breed goats were divided in five groups, each receiving a different antigen solution and saline buffer as a control. The humoral response was monitored through the identification of specific IgG by indirect ELISA and Western Blotting, and the production of IFN-g was followed in order to observe the activation of cellular response. After twelve weeks of antigen inoculation, the animals were challenged with 2 105 CFU of a wild strain, also isolated in Bahia, and necropsy was performed on all animals twelve weeks afterwards. It was observed that the attenuated bacteria gave a protection of 33.3%, in addition to the weak humoral response elicited. Animals inoculated with secreted antigen associated with
Freund’s incomplete adjuvant and oligodeoxynucleotide containing unmethylated CpG dinucleotides (CpG ODN) showed a strong
humoral response, but this inoculation could not prevent the spread of challenge bacteria in the majority of animals. These results
demonstrate the immunogenic potential of the attenuated T1 strain in the development of a vaccine against caseous lymphadenitis in
goats. | pt_BR |
dc.language.iso | en | pt_BR |
dc.subject | Caseous lymphadenitis | pt_BR |
dc.subject | Goats | pt_BR |
dc.subject | C. pseudotuberculosis | pt_BR |
dc.subject | CpG ODN | pt_BR |
dc.subject | Vaccine | pt_BR |
dc.title | Evaluation of the humoral and cellular immune response to different antigens of Corynebacterium pseudotuberculosis in Caninde´ goats and their potential protection against caseous lymphadenitis | pt_BR |
dc.title.alternative | Veterinary Immunology and Immunopathology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 126. | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS)
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