https://repositorio.ufba.br/handle/ri/5447
Campo DC | Valor | Idioma |
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dc.contributor.author | Almeida, Amanda Cristina Galvão Oliveira de | - |
dc.contributor.author | Quarantini, Lucas de Castro | - |
dc.contributor.author | Sampaio, Aline Santos | - |
dc.contributor.author | Lyra, André Castro | - |
dc.contributor.author | Parise, Carmen Lívia | - |
dc.contributor.author | Paraná, Raymundo | - |
dc.contributor.author | Oliveira, Irismar Reis de | - |
dc.contributor.author | Koenen, Karestan C. | - |
dc.contributor.author | Scippa, Ângela Marisa de Aquino Miranda | - |
dc.contributor.author | Guindalini, Camila | - |
dc.creator | Almeida, Amanda Cristina Galvão Oliveira de | - |
dc.creator | Quarantini, Lucas de Castro | - |
dc.creator | Sampaio, Aline Santos | - |
dc.creator | Lyra, André Castro | - |
dc.creator | Parise, Carmen Lívia | - |
dc.creator | Paraná, Raymundo | - |
dc.creator | Oliveira, Irismar Reis de | - |
dc.creator | Koenen, Karestan C. | - |
dc.creator | Scippa, Ângela Marisa de Aquino Miranda | - |
dc.creator | Guindalini, Camila | - |
dc.date.accessioned | 2012-02-25T15:04:11Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1090-2139 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5447 | - |
dc.description | texto completo: acesso restrito. p. 1491–1497. | pt_BR |
dc.description.abstract | Background: Major depression is a frequent adverse effect of interferon-alpha (IFN-a) therapy. Although the indoleamine 2,3-dioxygenase (IDO) enzyme seems to be involved in the pathophysiology of IFN-a-induced depression, no pharmacogenetic study has investigated whether variation in the IDO gene mod-ifies vulnerability to this adverse effect. Methods: A cross-sectional study assessing 277 hepatitis C patients recruited in two specialized outpa-tient clinics of Brazil. They were interviewed with the Mini International Neuropsychiatric Interview (MINI) approximately 1 month after the end of IFN-a plus ribavirin therapy. Genomic DNA of individuals was extracted from venous blood. Three IDO single-nucleotide polymorphisms (SNPs) were genotyped (rs3824259; rs10089084 and rs35099072).Results: MINI indicated that 21.3% of the sample met criteria for a major depressive episode during the course of IFN-a therapy. No association with the diagnosis of a major depressive episode during the course of IFN-a therapy was observed genotype or allele-wise (p > 0.05). Current major depression and/or current anxiety disorder was significantly associated with IFN-a-related depression (p < 0.005). However, gender, age, route of infection, result of the antiviral treatment, past history of substance use disorders, depression or any other psychiatric disorder showed no association with IFN-a-related depression (p > 0.05). Conclusions: Our results suggest no influence of the variants in the IDO gene and the diagnosis of inter- feron-a-related depression in the Brazilian population. Interferon-a-related depression may impose per-sistent psychopathology on at least 15% of the depressed patients even 2 years after antiviral therapy termination. The cross-sectional design is a limitation of our study, predisposing memory bias. Prospec- tive pharmacogenetic studies are warranted to continue investigation of the impact of IDO polymorphisms on the development of IFN-a-induced depression. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | doi:10.1016/j.bbi.2011.06.001 | pt_BR |
dc.subject | Genetic polymorphism | pt_BR |
dc.subject | Major depressive disorder | pt_BR |
dc.subject | Hepatitis C | pt_BR |
dc.subject | Interferon-alpha | pt_BR |
dc.subject | Pharmacogenetics | pt_BR |
dc.subject | Substance-related disorders | pt_BR |
dc.title | Lack of association of indoleamine 2,3-dioxygenase polymorphisms with interferon-alpha-related depression in hepatitis C | pt_BR |
dc.title.alternative | Brain, Behavior, and Immunity | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 25. | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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