https://repositorio.ufba.br/handle/ri/5548
Campo DC | Valor | Idioma |
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dc.contributor.author | Novoa, R. | - |
dc.contributor.author | Bacellar, Maria Olívia Amado Ramos | - |
dc.contributor.author | Nascimento, M. | - |
dc.contributor.author | Cardoso, T. M. | - |
dc.contributor.author | Ramasawmy, Rajendranath | - |
dc.contributor.author | Oliveira, W. N. | - |
dc.contributor.author | Schriefer, Nicolaus Albert Borges | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Novoa, R. | - |
dc.creator | Bacellar, Maria Olívia Amado Ramos | - |
dc.creator | Nascimento, M. | - |
dc.creator | Cardoso, T. M. | - |
dc.creator | Ramasawmy, Rajendranath | - |
dc.creator | Oliveira, W. N. | - |
dc.creator | Schriefer, Nicolaus Albert Borges | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-03-21T18:44:28Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0141-9838 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5548 | - |
dc.description | Acesso restrito: Texto completo. p. 132-136. | pt_BR |
dc.description.abstract | Cutaneous leishmaniasis (CL) is characterized by high production of pro-inflammatory cytokines and development of pathology. Individuals with subclinical L. braziliensis infection (SC) have a positive skin test to leishmania, but do not develop disease. We evaluated whether the downregulation of inflammatory response in SC is mediated by IL-10 and IL-27 and whether IL-17 is associated with control of infection. Participants include SC individuals, patients with CL and healthy subjects. Cytokines protein and mRNA were detected by ELISA and real-time PCR. IFN-c and TNF-a levels were higher in CL than in SC group. The IL-10 levels and mRNA for IL-10 were similar in both SC and CL. mRNA for IL-27 was increased in cells from SC after stimulation with L. braziliensis antigen. There was a tendency for increased levels of IL-17 in SC compared to CL. The weak type 1 immune response observed in SC L. braziliensis infection is not because of the regulatory effects of IL-10 and IL-27. The control of Leishmania infection may be mediated by innate immune response with participation of IL-17. The results from this pilot study warrant further larger studies to investigate the potential contributions of IL-17 and IL-27 to the control of L. braziliensis infection | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | DOI: 10.1111/j.1365-3024.2010.01256.x | pt_BR |
dc.subject | cutaneous leishmaniasis | pt_BR |
dc.subject | IL-17 | pt_BR |
dc.subject | Leishmania braziliensis | pt_BR |
dc.subject | regulatory cytokines | pt_BR |
dc.subject | subclinical infection | pt_BR |
dc.title | IL-17 and Regulatory Cytokines (IL-10 and IL-27) in L. braziliensis Infection | pt_BR |
dc.title.alternative | Parasite Immunology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 33, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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