Campo DC | Valor | Idioma |
dc.contributor.author | Seixas, Magda Oliveira | - |
dc.contributor.author | Rocha, Larissa C. | - |
dc.contributor.author | Carvalho, Mauricio B. | - |
dc.contributor.author | Menezes, Joelma Figueiredo | - |
dc.contributor.author | Lyra, Isa Menezes | - |
dc.contributor.author | Nascimento, Valma M. L. | - |
dc.contributor.author | Couto, Ricardo David | - |
dc.contributor.author | Atta, Ajax Mercês | - |
dc.contributor.author | Reis, Mitermayer G. | - |
dc.contributor.author | Goncalves, Marilda S. | - |
dc.creator | Seixas, Magda Oliveira | - |
dc.creator | Rocha, Larissa C. | - |
dc.creator | Carvalho, Mauricio B. | - |
dc.creator | Menezes, Joelma Figueiredo | - |
dc.creator | Lyra, Isa Menezes | - |
dc.creator | Nascimento, Valma M. L. | - |
dc.creator | Couto, Ricardo David | - |
dc.creator | Atta, Ajax Mercês | - |
dc.creator | Reis, Mitermayer G. | - |
dc.creator | Goncalves, Marilda S. | - |
dc.date.accessioned | 2012-04-19T13:06:48Z | - |
dc.date.available | 2012-04-19T13:06:48Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 1476-511X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/5650 | - |
dc.description | p. 1-9. | pt_BR |
dc.description.abstract | Background: The search for sickle cell disease (SCD) prognosis biomarkers is a challenge. These markers identification can help to establish further therapy, later severe clinical complications and with patients follow-up.We attempted to study a possible involvement of levels of high-density lipoprotein cholesterol (HDL-C) in steadystate children with SCD, once that this lipid marker has been correlated with anti-inflammatory, anti-oxidative, antiaggregation, anti-coagulant and pro-fibrinolytic activities, important aspects to be considered in sickle cell disease pathogenesis.
Methods: We prospectively analyzed biochemical, inflammatory and hematological biomarkers of 152 steady-state
infants with SCD and 132 healthy subjects using immunochemistry, immunoassay and electronic cell counter
respectively. Clinical data were collected from patient medical records.
Results: Of the 152 infants investigated had a significant positive association of high-density lipoprotein cholesterol
with hemoglobin (P < 0.001), hematocrit (P < 0.001) and total cholesterol (P < 0.001) and a negative significant
association with reticulocytes (P = 0.046), leukocytes (P = 0.015), monocytes (P = 0.004) and platelets (P = 0.005),
bilirubins [total bilirubin (P < 0.001), direct bilirubin (P < 0.001) and indirect bilirubin (P < 0.001], iron (P < 0.001),
aminotransferases [aspartate aminotransferase (P = 0.004), alanine aminotransferase (P = 0.035)], lactate
dehydrogenase (P < 0.001), urea (P = 0.030), alpha 1-antitrypsin (P < 0.001), very low-density lipoprotein cholesterol
(P = 0.003), triglycerides (P = 0.005) and hemoglobin S (P = 0.002). Low high-density lipoprotein cholesterol concentration was associated with the history of cardiac abnormalities (P = 0.025), pneumonia (P = 0.033) and blood transfusion use (P = 0.025). Lipids and inflammatory markers were associated with the presence of
cholelithiasis.
Conclusions: We hypothesize that some SCD patients can have a specific dyslipidemic subphenotype
characterized by low HDL-C with hypertriglyceridemia and high VLDL-C in association with other biomarkers,
including those related to inflammation. This represents an important step toward a more reliable clinical
prognosis. Additional studies are warranted to test this hypothesis and the probably mechanisms involved in this
complex network of markers and their role in SCD pathogenesis. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | DOI: 10.1186/1476-511X-9-91 | pt_BR |
dc.title | Levels of high-density lipoprotein cholesterol (HDL-C) among children with steady-state sickle cell disease | pt_BR |
dc.title.alternative | Lipids in Health and Disease | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 9 n. 9. | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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