https://repositorio.ufba.br/handle/ri/5673
Tipo: | Artigo de Periódico |
Título: | Flower cells in patients with infective dermatitis associated with HTLV-1 |
Título(s) alternativo(s): | Journal of Clinical Virology |
Autor(es): | Oliveira, Maria de Fátima Santos Paim de Vieira, Maria das Graças Leite Primo, Janeusa Rita Siqueira, Isadora C. Carvalho Filho, Edgar Marcelino de Farré, Lourdes Fatal, Priscila Lima Bittencourt, Achilea Candida Lisboa |
Autor(es): | Oliveira, Maria de Fátima Santos Paim de Vieira, Maria das Graças Leite Primo, Janeusa Rita Siqueira, Isadora C. Carvalho Filho, Edgar Marcelino de Farré, Lourdes Fatal, Priscila Lima Bittencourt, Achilea Candida Lisboa |
Abstract: | Background Infective dermatitis associated with HTLV-1 (IDH) is a severe childhood form of eczema that may progress to adult T-cell leukemia/lymphoma (ATL). Objectivo In this study, the presence of clinical and laboratory parameters suggestive of ATL was evaluated in a cohort of 30 patients with IDH.Study design Over a period of 33 months, the patients were submitted to three-monthly clinical evaluations, routine laboratory exams, full blood count and blood smears, and to six-monthly blood sampling for HTLV-1 proviral load determination. HTLV-1 proviral load was quantified using real-time TaqMan PCR assay. Results Abnormal cells (Ably) were found in the peripheral blood smears of nine patients (30%), flower cells being detected in five of these cases (16.6%). The presence of Ably and flower cells was not associated with a higher proviral load in those patients. Conclusions This is the first report on the presence of flower cells in HTLV-1-infected children and adolescents. Furthermore, these cells have not previously been reported in IDH patients. The cases with flower cells probably represent precursory ATL cases, these patients being at a greater risk of developing ATL. |
Palavras-chave: | HTLV-1 infection Infective dermatitisassociatedwithHTLV-1 Adult T-cellleukemia/lymphoma Flower cells Skin diseasescausedbyHTLV-1 |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5673 |
Data do documento: | 2010 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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