https://repositorio.ufba.br/handle/ri/5878
Tipo: | Artigo de Periódico |
Título: | Association of cytokines, neurological disability, and disease duration in HAM/TSP patients |
Título(s) alternativo(s): | Arq Neuropsiquiatr |
Autor(es): | Muniz, André Luís Nunes Rodrigues Junior, Waldyr Santos, Silvane Maria Braga Jesus, Amélia Maria Ribeiro de Porto, Maria Aurélia da Fonseca Castro, Néviton Matos de Oliveira Filho, Jamary Almeida, Juliana Passos Carvalho, Otavio Augusto Moreno de Carvalho Filho, Edgar Marcelino de |
Autor(es): | Muniz, André Luís Nunes Rodrigues Junior, Waldyr Santos, Silvane Maria Braga Jesus, Amélia Maria Ribeiro de Porto, Maria Aurélia da Fonseca Castro, Néviton Matos de Oliveira Filho, Jamary Almeida, Juliana Passos Carvalho, Otavio Augusto Moreno de Carvalho Filho, Edgar Marcelino de |
Abstract: | Objective: To identify clinical and immunological markers associated with HTLV-I associated myelopath y / tropical spastic paraparesis (HAM/TSP). Method: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame’s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. Results: 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. Conclusion: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a pro g ressive behavior of HAM/TSP. This study also shows that IFN-in PBMC supernatants are markers of HAM/TSP. |
Palavras-chave: | Human T-lymphotropic virus 1 Nervous system diseases Cytokines Neurological disability |
Editora / Evento / Instituição: | Associação Arquivos de Neuro-Psiquiatria Dr. Oswaldo Lange |
URI: | http://www.repositorio.ufba.br/ri/handle/ri/5878 |
Data do documento: | Jun-2006 |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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Muniz, André Luiz.pdf | 387,88 kB | Adobe PDF | Visualizar/Abrir |
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