https://repositorio.ufba.br/handle/ri/6032
Campo DC | Valor | Idioma |
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dc.contributor.author | Jesus, Amelia Ribeiro de | - |
dc.contributor.author | Luna, Tania | - |
dc.contributor.author | Almeida, Roque Pacheco de | - |
dc.contributor.author | Machado, Paulo Roberto Lima | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Jesus, Amelia Ribeiro de | - |
dc.creator | Luna, Tania | - |
dc.creator | Almeida, Roque Pacheco de | - |
dc.creator | Machado, Paulo Roberto Lima | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-05-31T18:39:31Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6032 | - |
dc.description | Acesso restrito: Texto completo. p. 1344-1353. | pt_BR |
dc.description.abstract | Tumor necrosis factor-α (TNF-α) is known to have numerous biological properties relating to inflammation. This cytokine participates in the tissue damage of chronic inflammatory, autoimmune and infectious diseases. Pentoxifylline is a methylxanthine that inhibits phosphodiesterase IV, which inhibits the degradation of the cAMP and prostanoids. The increased intracellular concentration of the cAMP leads to a negative regulation of NF-κB and NF-AT transcription factors and suppresses TNF-α production. This review describes studies that support evidences that TNF-α is involved in the pathogenesis of HTLV-1 associated myelopathy and of cutaneous and mucosal leishmaniasis. Additionally, it demonstrates the effect of pentoxifylline in vitro in inhibiting TNF-α and IFN-γ spontaneous production in PBMC from HTLV-1-infected patients, as well as its in vivo effect in inhibiting TNF-α in sera from mucosal leishmaniasis patients. Moreover, we review the results of clinical studies from the last 10 years using pentoxifylline to treat HTLV-1 associated myelopathy and cutaneous and mucosal leishmaniasis. © 2008 Elsevier B.V. All rights reserved. | pt_BR |
dc.language.iso | en | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.intimp.2008.03.020 | pt_BR |
dc.subject | Pentoxifylline | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | Leishmaniasis | pt_BR |
dc.subject | Cutaneous leishmaniasis | pt_BR |
dc.subject | Mucosal leishmaniasis | pt_BR |
dc.subject | Immunotherapy | pt_BR |
dc.title | Pentoxifylline down modulate in vitro Tcell responses and attenuate pathology in Leishmania and HTLV-I infections | pt_BR |
dc.title.alternative | International Immunopharmacology | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 8, n. 10 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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