https://repositorio.ufba.br/handle/ri/6048
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Atta, Ajax Mercês | - |
dc.contributor.author | Oliveira, Isabela S. | - |
dc.contributor.author | Sousa, Gabriel Menezes de | - |
dc.contributor.author | Paraná, Raymundo | - |
dc.contributor.author | Atta, Maria Luiza Brito de Sousa | - |
dc.creator | Atta, Ajax Mercês | - |
dc.creator | Oliveira, Isabela S. | - |
dc.creator | Sousa, Gabriel Menezes de | - |
dc.creator | Paraná, Raymundo | - |
dc.creator | Atta, Maria Luiza Brito de Sousa | - |
dc.date.accessioned | 2012-06-01T18:34:47Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0882-4010 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6048 | - |
dc.description | Trabalho completo: acesso restrito, p. 53–56 | pt_BR |
dc.description.abstract | This work investigated the serum cytokine profile (IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF) of hepatitis C virus (HCV) carriers with autoimmunity. Forty-seven HCV carriers and 28 healthy controls were evaluated. Cytokine levels were measured by ELISA. Patients and controls presented similar levels of IL-2, IL-4, IL-5, IL-10, IFN-γ and BAFF (p > 0.05). Cryoglobulinaemic HCV carriers had increased IL-2 (p = 0.013), IL-5 (p = 0.018) and BAFF (p = 0.050). IFN-γ level was decreased in HCV carriers with rheumatoid factor in comparison with those that were RF-seronegative (p = 0.035). Patients with β2GPI IgA antibodies when were compared with those without this autoantibody, had more serum IL-2 (p = 0.009), IL-5 (p = 0.018) and BAFF (p = 0.039). Interleukin-2 was increased in HCV carriers with positive ANA when they were compared with ANA-seronegative carriers (p = 0.044). Interleukins IL-4 and IL-10 were not associated with autoimmunity (P > 0.05). In HCV carriers, IL-2 was correlated with IL-5 (p < 0.0001) and IFN-γ (p = 0.015), and IL-5 with IFN-γ (p = 0.015). We concluded that the serum profile of cytokines in HCV carriers presenting autoimmune markers may be mainly represented by increased IL-2, IL-5 and BAFF. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.micpath.2009.12.002 | pt_BR |
dc.subject | Hepatitis C | pt_BR |
dc.subject | Autoimmunity | pt_BR |
dc.subject | Cryoglobulinaemia | pt_BR |
dc.subject | Autoantibody | pt_BR |
dc.subject | Cytokine | pt_BR |
dc.title | Serum cytokine profile in hepatitis C virus carriers presenting cryoglobulinaemia and non-organ-specific autoantibodies | pt_BR |
dc.title.alternative | Microbial Pathogenesis | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 48, n. 2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
(46)1-s2.0-S0882401009002022-main.pdf Restricted Access | 214,55 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.