https://repositorio.ufba.br/handle/ri/6272
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Xavier, Flávia Caló de Aquino | - |
dc.contributor.author | Rodini, Camila Oliveira | - |
dc.contributor.author | Ramalho, Luciana Maria Pedreira | - |
dc.contributor.author | Mantesso, Andrea | - |
dc.contributor.author | Nunes, Fabio Daumas | - |
dc.creator | Xavier, Flávia Caló de Aquino | - |
dc.creator | Rodini, Camila Oliveira | - |
dc.creator | Ramalho, Luciana Maria Pedreira | - |
dc.creator | Mantesso, Andrea | - |
dc.creator | Nunes, Fabio Daumas | - |
dc.date.accessioned | 2012-06-29T18:01:37Z | - |
dc.date.issued | 2009 | - |
dc.identifier.issn | 0904-2512 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6272 | - |
dc.description | Trabalho completo: acesso restrito, p. 708–715 | pt_BR |
dc.description.abstract | Oncogenic Wnt/b-catenin signaling occurs in numerous types of cancers, but little is known about the role of the Wnt protein family member, WNT- 5A, in lip carcinogenesis. The aim of this study was to investigate WNT-5A, b-catenin, and matrix metalloproteinase (MMP)-3 protein expression in actinic cheilitis (AC), and lip squamous cell carcinoma (LSCC). METHODS: Twenty-one cases of AC, and fifty-one cases of LSCC were analyzed, with normal lip mucosa used as a control. Qualitative and semi-quantitative analyses of WNT-5A, b-catenin, and MMP-3 immunostaining pattern and cellular distribution were performed. RESULTS: WNT-5A was observed in more than 50% of the cells, scattered in all layers of AC, in contrast to the absence of immunostaining in normal lip mucosa. AC presented a higher level of WNT-5A expression than LSCC (P = 0.0289, Fisher test), while MMP-3 immunoexpression was statistically more significant in LSCC than in AC (P = 0.0285, Fisher test). Immunolabeling of b-catenin protein was differentially distributed between samples; the majority of AC cases (61.90%) demonstrated a membranous-cytoplasmic pattern, while a considerable number of LSCC cases (29.41%) revealed a cytoplasmic pattern, instead of the usual membranous pattern. CONCLUSIONS: The present results suggest that WNT-5A may be an important marker during initial events of AC malignant transformation, in which noncanonical and canonical Wnt/b-catenin signaling pathways could be involved. Additionally, WNT-5A might recruit other events in LSCC, such as MMP-3 protein synthesis, as its presence is increased in established malignant processes without b-catenin dependency. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | John Wiley and Sons | pt_BR |
dc.source | http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0714.2009.00756.x/pdf | pt_BR |
dc.subject | actinic cheilitis | pt_BR |
dc.subject | MMP-3 | pt_BR |
dc.subject | squamous cell carcinoma | pt_BR |
dc.subject | WNT-5A protein | pt_BR |
dc.subject | b-catenin | pt_BR |
dc.title | WNT-5A, but not matrix metalloproteinase 3 or b-catenin protein, expression is related to early stages of lip carcinogenesis | pt_BR |
dc.title.alternative | Journal of Oral Pathology and Medicine | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 38, n. 9 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Odontologia) |
Arquivo | Descrição | Tamanho | Formato | |
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(94)j.1600-0714.2009.00756.x.pdf Restricted Access | 710,45 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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