https://repositorio.ufba.br/handle/ri/6553
Campo DC | Valor | Idioma |
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dc.contributor.author | Ferreira, Hilda Silva | - |
dc.contributor.author | Oliveira, Elenilda | - |
dc.contributor.author | Faustino, Thiallan Nery | - |
dc.contributor.author | Silva, Emilio de Castro e | - |
dc.contributor.author | Fregoneze, Josmara Bartolomei | - |
dc.creator | Ferreira, Hilda Silva | - |
dc.creator | Oliveira, Elenilda | - |
dc.creator | Faustino, Thiallan Nery | - |
dc.creator | Silva, Emilio de Castro e | - |
dc.creator | Fregoneze, Josmara Bartolomei | - |
dc.date.accessioned | 2012-08-07T17:26:12Z | - |
dc.date.issued | 2005-04-08 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6553 | - |
dc.description | Trabalho completo: acesso restrito, p.64–72 | pt_BR |
dc.description.abstract | n the present study we investigated the role of central 5-HT2C receptors in the control of blood pressure and heart rate in non-stressed and stressed, adult, male, Wistar rats. Third ventricle injections of the 5-HT2C agonist mCPP elicited a significant increase in blood pressure in non-stressed animals. The initial period of this hypertensive response (10–30 min after mCPP administration) was accompanied by baroreflex-mediated bradycardia, while after this period the coexistence of hypertension and tachycardia was observed. These cardiovascular effects promoted by the central administration of mCPP were blocked by pretreatment with the 5-HT2C antagonist, SDZ SER 082. The administration of SDZ SER 082 alone induced no significant changes in blood pressure or heart rate. The pharmacological stimulation of central 5-HT2C receptors by mCPP did not change the hypertensive or tachycardic responses induced by restraint stress. Conversely, the blockade of central 5-HT2C receptors by SDZ SER 082 blunted stress-induced hypertension without modifying stress-induced tachycardia. It is concluded that the activation of central 5-HT2C receptors induces hypertension in non-stressed rats and that the normal function of these receptors is essential for the rise in blood pressure that occurs in the course of restraint stress. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.brainres.2005.01.054 | pt_BR |
dc.subject | Endocrine and autonomic regulation | pt_BR |
dc.subject | Cardiovascular regulation | pt_BR |
dc.title | Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats | pt_BR |
dc.title.alternative | Brain Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v.1040, n. 1–2 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (ICS) |
Arquivo | Descrição | Tamanho | Formato | |
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(148).pdf Restricted Access | 204,07 kB | Adobe PDF | Visualizar/Abrir Solicitar uma cópia |
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