https://repositorio.ufba.br/handle/ri/6573
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Barreto, George Emílio Sampaio | - |
dc.contributor.author | Santos, Gleide Souza dos | - |
dc.contributor.author | Egito, Eryvaldo Sócrates Tabosa | - |
dc.contributor.author | El-Bachá, Ramon dos Santos | - |
dc.creator | Barreto, George Emílio Sampaio | - |
dc.creator | Santos, Gleide Souza dos | - |
dc.creator | Egito, Eryvaldo Sócrates Tabosa | - |
dc.creator | El-Bachá, Ramon dos Santos | - |
dc.date.accessioned | 2012-08-09T14:25:04Z | - |
dc.date.available | 2012-08-09T14:25:04Z | - |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1678-2674 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6573 | - |
dc.description | p.40-45 | pt_BR |
dc.description.abstract | PURPOSE: The aim of this work was to investigate the hypothesis that catechol inhibits FADH2-linked basal respiration in mitochondria isolated from rat liver homogenates. Moreover, catechol ability to induce peroxidation of biomolecules in liver nuclear fractions was also studied. METHODS: Rat liver homogenates were incubated with 1mM 1,2-dihydroxybenzene (catechol) at pH 7.4 for up to 30 minutes. After that, mitochondrial fractions were isolated by differential centrifugation. Basal oxygen uptake was measured using a Clark-type electrode after the addition of 10 mM sodium succinate. Nuclear fractions were incubated in the presence of 1 mM catechol for 17 hours at room temperature and the peroxidation of biomolecules was investigated by the reaction with thiobarbituric acid, which was determined spectrophotometrically at 535 nm. RESULTS: Catechol induced a time-dependent partial inhibition of FADH2-linked basal mitochondrial respiration, however this substance was unable to induce a direct peroxidation of biomolecules in hepatic nuclear fractions. CONCLUSION: Catechol produced an inhibition of basal respiration associated to FADH2 in isolated liver mitochondria that could lead to cytotoxicity, ROS generation and cell death. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Acta Cirúrgica Brasileira/SOBRADPEC | pt_BR |
dc.source | http://dx.doi.org/10.1590/S0102-86502005000700008 | pt_BR |
dc.subject | Catechol | pt_BR |
dc.subject | Mitochondrial respiration | pt_BR |
dc.subject | Peroxidation | pt_BR |
dc.title | Catechol inhibits FADH2-linked respiration in rat liver mitochondrial fraction | pt_BR |
dc.title.alternative | Acta Cirurgica Brasileira | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | São Paulo | pt_BR |
dc.identifier.number | v. 20, n. 1 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
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