https://repositorio.ufba.br/handle/ri/6674
Campo DC | Valor | Idioma |
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dc.contributor.author | Favali, Cecilia Beatriz Fiuza | - |
dc.contributor.author | Costa, Dirceu Joaquim | - |
dc.contributor.author | Macêdo, Lilian Maria Afonso de | - |
dc.contributor.author | Conceição, Viviane | - |
dc.contributor.author | Rosato, Andréa Bomura | - |
dc.contributor.author | Oliveira, Luiz Fabiano Borges | - |
dc.contributor.author | Costa, Jackson Mauricio Lopes | - |
dc.contributor.author | Barral, Aldina Maria Prado | - |
dc.contributor.author | Barral-Netto, Manoel | - |
dc.contributor.author | Brodskyn, Claudia Ida | - |
dc.creator | Favali, Cecilia Beatriz Fiuza | - |
dc.creator | Costa, Dirceu Joaquim | - |
dc.creator | Macêdo, Lilian Maria Afonso de | - |
dc.creator | Conceição, Viviane | - |
dc.creator | Rosato, Andréa Bomura | - |
dc.creator | Oliveira, Luiz Fabiano Borges | - |
dc.creator | Costa, Jackson Mauricio Lopes | - |
dc.creator | Barral, Aldina Maria Prado | - |
dc.creator | Barral-Netto, Manoel | - |
dc.creator | Brodskyn, Claudia Ida | - |
dc.date.accessioned | 2012-08-31T19:17:31Z | - |
dc.date.issued | 2005-01 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6674 | - |
dc.description | Trabalho completo: acesso restrito, p. 86–92 | pt_BR |
dc.description.abstract | T cell-mediated immunity is critical in resistance against Leishmania parasites, and T cell activation requires signals provided by costimulatory molecules. Herein we evaluated the role of costimulatory molecules on cytokine production and T cell surface molecule expression by peripheral blood mononuclear cells (PBMC) from cutaneous leishmaniasis (CL) patients. PBMC from CL patients were stimulated with soluble Leishmania antigen (SLA, 10 μg/ml), in the presence or absence of soluble CTLA4-Ig to block CD28-B7 interaction or in the presence or absence of anti-human CD40L to block CD40-CD40L interaction. Supernatants were harvested to evaluate tumor necrosis factor alpha (TNF-α), interleukin 10 (IL-10), transforming growth factor beta (TGF-β) and interferon gamma (IFN-γ) production by ELISA. Cells were harvested after 48 h of culture, stained for specific activation markers and analyzed by flow cytometry. Results show that the blockade of CD28-B7 interaction by CTLA4-Ig downmodulated IFN-γ, IL-10, and TNF-α secretion by PBMC from CL patients. No alteration was detected on either TGF-β production or the expression of CTLA44 or CD25 on CD4+ and CD8+ T cells. When the CD40-CD40L interaction was blockade using anti-CD40L, we did not observe changes in cytokine production or in surface molecule expression. The blockade of the CD28-B7 interactions by CTLA4-Ig also did not alter cytokine production in volunteers immunized against tetanus toxoid (TT). Taken together, these data suggest that the interaction of CTLA4 and CD28-B7 is a TGF-β-independent mechanism that specifically downmodulates the immune response in cutaneous leishmaniasis patients. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Elsevier | pt_BR |
dc.source | http://dx.doi.org/10.1016/j.micinf.2004.09.015 | pt_BR |
dc.subject | Cutaneous leishmaniasis | pt_BR |
dc.subject | Cytokines | pt_BR |
dc.subject | Immunomodulation | pt_BR |
dc.title | Role of costimulatory molecules in immune response of patients with cutaneous leishmaniasis | pt_BR |
dc.title.alternative | Microbes and Infection | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.identifier.number | v. 7, n. 1 | pt_BR |
dc.embargo.liftdate | 10000-01-01 | - |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina) |
Arquivo | Descrição | Tamanho | Formato | |
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