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Use este identificador para citar ou linkar para este item: https://repositorio.ufba.br/handle/ri/6702
Tipo: Artigo de Periódico
Título: Evaluating total lymphocyte counts as a substitute for CD4 counts in the follow up of AIDS patients
Título(s) alternativo(s): Brazilian Journal of Infectious Diseases
Autor(es): Angelo, Ana Luiza Dias
Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
Autor(es): Angelo, Ana Luiza Dias
Angelo, Camila Dias
Torres, Alex José Leite
Ramos, André Maurício Costa
Lima, Márcia
Martins Netto, Eduardo
Brites, Carlos
Abstract: This study evaluated total lymphocyte count (TLC) as a substitute marker for CD4+ cell counts to identify patients who need prophylaxis against opportunistic infection (CD4 < 200 cells/mm3) and patients with CD4 < 350 cells/mm3 (Brazilian threshold value of CD4 count to define AIDS). We evaluated TLC and CD4+ cells count of 1,174 HIV-infected patients, in Salvador, Brazil, from May 2003 to September 2004. CD4+ cell counts were performed by flow cytometry, and TLC was measured with an automated hematological counter. The mean CD4 count was 430 cells/mm3 (range: 4 to 2,531 cells/mm3). Mean TLC was 1,900 cells/mm3 (range: 300 to 6,200 cells/mm3). Using a threshold value of 1,000 cells/mm3 for TLC, the positive predictive value (PPV) was 77% for CD4 < 200 cells/mm3, but the sensitivity was only 29%, while the negative predictive value (NPV) was 88%, with 98% specificity. Similar findings were observed for CD4 count < 350. Using the same threshold value of 1,000 cells/mm3 for TLC, sensitivity was 14%, and specificity 99% (PPV= 94%; NPV=62%). In 70/1,510 (5%) of the samples the sum of CD4 and CD8 cell counts was greater than the TLC and in 27% (419/1,510) this sum was below 65% of the TLC. TLC has a high specificity to identify patients for prophylaxis, but a quite low sensitivity. It is not useful as an alternative to CD4+ T-cell counts as a marker in HIV-infected patients.
Palavras-chave: Lymphocyte counts
CD4 counts
AIDS
Editora / Evento / Instituição: The Brazilian Journal of Infectious Diseases and Contexto Publishing
URI: http://www.repositorio.ufba.br/ri/handle/ri/6702
Data do documento: Out-2007
Aparece nas coleções:Artigo Publicado em Periódico (Faculdade de Medicina)

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