https://repositorio.ufba.br/handle/ri/6828
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Castro, L. | - |
dc.contributor.author | Varjão, B. | - |
dc.contributor.author | Silva, I. | - |
dc.contributor.author | Duque, Bruno | - |
dc.contributor.author | Batista, A. | - |
dc.contributor.author | Santana, R. | - |
dc.contributor.author | Luz, P. | - |
dc.contributor.author | Rocha Junior, M. A. | - |
dc.contributor.author | Fregoneze, J. B. | - |
dc.contributor.author | Castro e Silva, E. de | - |
dc.creator | Castro, L. | - |
dc.creator | Varjão, B. | - |
dc.creator | Silva, I. | - |
dc.creator | Duque, Bruno | - |
dc.creator | Batista, A. | - |
dc.creator | Santana, R. | - |
dc.creator | Luz, P. | - |
dc.creator | Rocha Junior, M. A. | - |
dc.creator | Fregoneze, J. B. | - |
dc.creator | Castro e Silva, E. de | - |
dc.date.accessioned | 2012-09-28T20:31:18Z | - |
dc.date.available | 2012-09-28T20:31:18Z | - |
dc.date.issued | 2001-06 | - |
dc.identifier.issn | 1414-431X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6828 | - |
dc.description | p.791-796 | pt_BR |
dc.description.abstract | We demonstrate here that acute third ventricle injections of GR 113808, a highly selective 5-HT4 antagonist, decrease water intake induced by a previous salt load while potentiating drinking elicited by hypovolemia induced by previous subcutaneous administration of polyethylene glycol in male Wistar rats (200 ± 20 g). At the dose of 160 nmol/rat, third ventricle injections of GR 113808 induced a significant reduction of water intake in salt-loaded animals after 120 min as compared to salt-loaded animals receiving third ventricle injections of saline (salt load + GR = 3.44 ± 0.41 ml, N = 12; salt load + saline = 5.74 ± 0.40 ml, N = 9). At the dose of 80 nmol/rat, GR 113808 significantly enhanced water intake in hypovolemic animals after 120 min as compared to hypovolemic animals receiving third ventricle injections of saline (hypovol + GR = 4.01 ± 0.27 ml, N = 8; hypovol + saline = 2.41 ± 0.23 ml, N = 12). We suggest that central 5-HT4 receptors may exert a positive drive on water intake due to hyperosmolarity and a negative input on drinking provoked by hypovolemia. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.source | http://dx.doi.org/10.1590/S0100-879X2001000600015 | pt_BR |
dc.subject | 5-HT4 receptors | pt_BR |
dc.subject | Water intake | pt_BR |
dc.subject | Hyperosmolarity | pt_BR |
dc.subject | Hypovolemia | pt_BR |
dc.title | Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Ribeirão Preto | pt_BR |
dc.identifier.number | v. 34, n. 6 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Biologia) |
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