Campo DC | Valor | Idioma |
dc.contributor.author | Guerreiro, Jaqueline B. | - |
dc.contributor.author | Porto, Maria Aurélia da Fonseca | - |
dc.contributor.author | Santos, Silvane Maria Braga | - |
dc.contributor.author | Lacerda, Lino | - |
dc.contributor.author | Ho, John L. | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Guerreiro, Jaqueline B. | - |
dc.creator | Porto, Maria Aurélia da Fonseca | - |
dc.creator | Santos, Silvane Maria Braga | - |
dc.creator | Lacerda, Lino | - |
dc.creator | Ho, John L. | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.date.accessioned | 2012-10-10T19:01:59Z | - |
dc.date.available | 2012-10-10T19:01:59Z | - |
dc.date.issued | 2005 | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6927 | - |
dc.description | p. 510-514 | pt_BR |
dc.description.abstract | Human T cell lymphotropic Virus type-1 (HTLV-1) induces lymphocyte activation and
proliferation, but little is known about the innate immune response due to HTLV-1 infection. We
evaluated the percentage of neutrophils that metabolize Nitroblue tetrazolium (NBT) to formazan
in HTLV-1 infected subjects and the association between neutrophil activation and IFN-γ and TNF-
α levels. Blood was collected from 35 HTLV-1 carriers, from 8 patients with HAM/TSP (HTLV-1-
associated myelopathy); 22 healthy individuals were evaluated for spontaneous and
lipopolysaccharide (LPS)-stimulated neutrophil activity (reduction of NBT to formazan). The
production of IFN-γ and TNF-α by unstimulated mononuclear cells was determined by ELISA.
Spontaneous NBT levels, as well as spontaneous IFN-γ and TNF-α production, were significantly
higher (p<0.001) in HTLV-1 infected subjects than in healthy individuals. A trend towards a
positive correlation was noted, with increasing percentage of NBT positive neutrophils and levels
of IFN-γ. The high IFN-γ producing HTLV-1 patient group had significantly greater NBT than
healthy controls, 43+24% and 17+4.8% respectively (p< 0.001), while no significant difference
was observed between healthy controls and the low IFN-γ-producing HTLV-1 patient group
(30+20%). Spontaneous neutrophil activation is another marker of immune perturbation resulting
from HTLV-1 infection. In vivo activation of neutrophils observed in HTLV-1 infected subjects is
likely to be the same process that causes spontaneous IFN-γ production, or it may partially result
from direct IFN-γ stimulation. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | The Brazilian Journal of Infectious Diseases | pt_BR |
dc.subject | HTLV-1 | pt_BR |
dc.subject | IFN-γ | pt_BR |
dc.subject | TNF-α | pt_BR |
dc.subject | LPS | pt_BR |
dc.subject | neutrophil activation | pt_BR |
dc.title | Spontaneous Neutrophil Activation in HTLV-1 Infected Patients | pt_BR |
dc.title.alternative | The Brazilian Journal of Infectious Diseases | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Salvador | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
|