Campo DC | Valor | Idioma |
dc.contributor.author | Leite Primo, Janeusa Rita | - |
dc.contributor.author | Siqueira, I. | - |
dc.contributor.author | Nascimento, M. C. F. | - |
dc.contributor.author | Oliveira, M. F. | - |
dc.contributor.author | Farré, Lourdes | - |
dc.contributor.author | Carvalho Filho, Edgar Marcelino de | - |
dc.contributor.author | Bittencourt, Achilea Candida Lisboa | - |
dc.creator | Leite Primo, Janeusa Rita | - |
dc.creator | Siqueira, I. | - |
dc.creator | Nascimento, M. C. F. | - |
dc.creator | Oliveira, M. F. | - |
dc.creator | Farré, Lourdes | - |
dc.creator | Carvalho Filho, Edgar Marcelino de | - |
dc.creator | Bittencourt, Achilea Candida Lisboa | - |
dc.date.accessioned | 2012-10-17T14:16:25Z | - |
dc.date.available | 2012-10-17T14:16:25Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.issn | 1414-431X | - |
dc.identifier.uri | http://www.repositorio.ufba.br/ri/handle/ri/6979 | - |
dc.description | p.761-764 | pt_BR |
dc.description.abstract | Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP. | pt_BR |
dc.language.iso | en | pt_BR |
dc.publisher | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.source | http://dx.doi.org/10.1590/S0100-879X2009005000008 | pt_BR |
dc.subject | Infective dermatitis associated with HTLV-1 | pt_BR |
dc.subject | HTLV-1 associated myelopathy/tropical spastic paraparesis | pt_BR |
dc.subject | HTLV-1 proviral loads | pt_BR |
dc.title | High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1 | pt_BR |
dc.title.alternative | Brazilian Journal of Medical and Biological Research | pt_BR |
dc.type | Artigo de Periódico | pt_BR |
dc.description.localpub | Ribeirão Preto | pt_BR |
dc.identifier.number | v. 42, n. 8 | pt_BR |
Aparece nas coleções: | Artigo Publicado em Periódico (Faculdade de Medicina)
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